Investigate the effect of the Etomidatelevel on the seizure-quality of a seizure caused bij electroconvulsive therapy
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Seizure-quality measured with on the basis of the length of the motorial
seizure, the length of the seizure on EEG, Seizure Energy Index and Post-ictal
Suppression Index.
Secondary outcome
Level of wellbeing after ECT
the course of the Etomidate level during time.
Background summary
Electroconvulsive therapy is a proved treatment for various psychiatric
diseases. In each treatment a seizure is caused, and takes place in the
operating rooms. The treatment is accomplished by a psychiatrist and an
anaesthetist, who takes care of the anaesthesia. In the Sint Elisabeth
hospital Etomidate and Succinylcholine are used as anaesthetics. Etomidate
also works anticonvulsive.
Study objective
Investigate the effect of the Etomidatelevel on the seizure-quality of a
seizure caused bij electroconvulsive therapy
Study design
Randomised dubble blind intervention study, in witch the time between
administer Ethomidate and caused seizure will be varied.
Intervention
During one ECT blood will be achieved on various moments after administration
of Etomidate for measurement of the Etomidate levels. During the following
treatments the time between administer Ethomidate and caused seizure will be
varied. Afterwards the patients are asked to record the level of wellbeing on a
visual analogue scale
Study burden and risks
There are few differences compared to the regular ECT. During one treatment
blood is taken. As in regular medical care, the anaesthetist ensures that a
patient is under anaesthesia before an ECT will be caused. The risks are the
same as in regular ECT.
Hilvarenbeekseweg 60
5022 GC Tilburg
Nederland
Hilvarenbeekseweg 60
5022 GC Tilburg
Nederland
Listed location countries
Age
Inclusion criteria
Indication for ECT
Exclusion criteria
Less then 10 ECT's expected
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29186.008.09 |