effects of age on neural blockade and cardiovascular parameters after thoracic epidural anesthesia
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
lokaal anestheticum gebruikt voor epidurale anesthesie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Neural blockade:
Time to initial onset of analgesia at the T3-T4 dermatomes
Time to initial onset of motor blockade
Time until maximum cephalad spread of analgesia
Time until maximum caudad spread of analgesia
Highest level of analgesia
Maximum numbers of segments blocked
Maximum score of motor block (Bromage scale and ESSAM score)
Cardiovascular:
Left ventricle systolic function
Left ventricle diastolic function
right ventricle systolic function
Secondary outcome
not applicable
Background summary
The fraction of the population aged 65 years and older is growing very fast.
Persons aged 65 years and older now constitute 14 % of the total Dutch
population and it is expected that this same group will constitute 23 % of the
Dutch population in 2040 (CBS: online).
Lung cancer becomes mostly manifest in the geriatric population [1] and
surgical resection is one of the standard therapies. It is to be expected that
there will be an increase in the incidence of elderly people presenting with
resectable malignancy. Thoracic epidural anesthesia (TEA) combined with general
anesthesia (GA) is common practice for this kind of surgery.
To our knowledge there is no study that has tested the influence of age on the
extension of neural blockade after thoracic epidural injection of ropivacaine.
It's not known if thoracic epidural anesthesia is influenced by the
physiological changes associated with increasing age.
Study objective
effects of age on neural blockade and cardiovascular parameters after thoracic
epidural anesthesia
Study design
Prospective observational single center study
Study burden and risks
not applicable
Albinusdreef 2
2333 ZA
NL
Albinusdreef 2
2333 ZA
NL
Listed location countries
Age
Inclusion criteria
male and female patients
ASA I-III
patients undergoing thoracic surgery under thoracic epidural anesthesia
Exclusion criteria
Diabetes mellitus
Infection of the skin in the area of the epidural site
A history of neurological diseases
A history of bleeding diathesis
Muscle diseases
Hypersensitive to local anesthetics
Pregnancy or lactation
Participation in a trial on investigational drugs within 3 months prior to the study
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| EudraCT | EUCTR2009-010594-20-NL |
| CCMO | NL27041.058.09 |