To investigate whether local inflammation in the area of the stomach and gastroenteric anastomosis is a cause of primary DGE.
ID
Source
Brief title
Condition
- Malignant and unspecified neoplasms gastrointestinal NEC
- Hepatobiliary neoplasms malignant and unspecified
- Gastrointestinal therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Inflammatory activity in the area of stomach and gastroenteric anastomosis,
expressed as intestinal SUV-max.
Secondary outcome
Not applicable
Background summary
Delayed gastric emptying (DGE) is one of the most common complications after
pancreatoduodenectomy (PD). Etiology of primary DGE is unknown. Local
intra-abdominal inflammation may cause DGE. PET/CT using 18F-FDG-labelled white
blood cells can detect such focal sites of inflammation.
Study objective
To investigate whether local inflammation in the area of the stomach and
gastroenteric anastomosis is a cause of primary DGE.
Study design
Prospective cohort study; observational study with invasive measurements
Study burden and risks
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness: No negative side effects of the PET/CT using
18F-FDG labelled white blood cells have been described. In this patient group,
evidence supporting that local inflammation is a causative mechanism of primary
DGE may offer treatment options
Postbus 22660
1100 DD Amsterdam
NL
Postbus 22660
1100 DD Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Scheduled for explorative laparotomy with intention of pancreatoduodenectomy for pancreatic or periampullary disease
Age >/<= 18 years
Willing and able to give written informed consent
Exclusion criteria
Peroperative findings of unresectability
Secondary DGE (DGE due to other intra-abdominal complications)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29061.018.09 |