The aim of the present study is to investigate cerebral vasoreactivity in response to lower body negative pressure in young and elderly healthy men, as a measure of cerebral autoregulatory responsiveness.
ID
Source
Brief title
Condition
- Structural brain disorders
- Decreased and nonspecific blood pressure disorders and shock
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Change in (regional) cerebral blood flow and cerebral blood volume.
Secondary outcome
Cerebral blood flow velocity of main feeding cerebral arteries, continuous
blood pressure and heart frequency.
Background summary
Although hypertension in midlife is associated with an increased risk of
dementia in late- life, in late-life cognitive impairment is associated with
lower blood pressures. Possibly, higher blood pressures are needed to maintain
an adequate brain perfusion with a possible increasing failure of cerebral
autoregulation with increasing age.
Study objective
The aim of the present study is to investigate cerebral vasoreactivity in
response to lower body negative pressure in young and elderly healthy men, as a
measure of cerebral autoregulatory responsiveness.
Study design
Intervention study with intra-individual paired measurements for measuring the
effect of intervention and case-control design for the comparison between the
effect in young and older study subjects.
Intervention
Lower body negative pressure (LBNP).
Study burden and risks
The study is not a great burden for study subjects. There is a possibility that
the application of LBNP will be experienced as uncomfortable. There is a
minimal chance that study subjects lose consciousness. The direct release of
LBNP will result in a fast recovery, without any remaining complaints.
Albinusdreef 2
2333 ZA Leiden
Nederland
Albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
- age: 18-35 years and >70 years
- non-smoking
- body mass index: 18-28 kg/m2
- length: 160-190 cm
Exclusion criteria
- medical history of cardiovascular disease, diabetes mellitus, pulmonary disease, neurological disease, malignant disease, venous insufficiency
- alcohol use >3 units / day
- use of systemic medication
- cognitive impairment (MMSE score < 28 points)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL27396.058.09 |