The aim of this study is to assess the relation between elevated FENO and undiagnosed asthma.
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters are the ISAAC questionnaire for asthma, rhinitis and
eczema, spirometry (FEV1 and FVC), airway reversibility testing with salbutamol
and FENO. Sensitivity, specificity, positive predictive value (PPV) and
negative predictive value (NPV) of FENO and airway reversibility in undiagnosed
asthma in children aged 7-10 years will be analysed.
Secondary outcome
Not applicable
Background summary
The results of the clinical and epidemiological studies up until now urge the
need for further studies on the usefulness of FENO (fractional exhaled nitric
oxide) in the clinical management of undiagnosed asthma. In subjects aged 7-10
years there is a window of opportunity to diagnose childhood asthma through the
combination of clinical data and spirometric lung function including FENO as a
measure of airway inflammation.
Study objective
The aim of this study is to assess the relation between elevated FENO and
undiagnosed asthma.
Study design
The design of this study is a cross-sectional study in all primary care centres
in Brielle, the Netherlands.
Study burden and risks
The burden of participation is to complete the ISAAC questionnaire and to
having assessed length, height, FEV1, FVC, reversibility of airway obstruction
with salbutamol and FENO in one visit. Short during side effects of salbutamol
can be an additional flavour in the mouth after inhalation or more common
symptoms as nausea or headache.
Slagveld 42
3231AP Brielle
Nederland
Slagveld 42
3231AP Brielle
Nederland
Listed location countries
Age
Inclusion criteria
alle children aged 7-10 years
Exclusion criteria
Children with a doctor*s diagnosis of asthma and asthma medication in the past twelve months.
Children with a contra-indication for salbutamol.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL26360.078.08 |