The goal of our research is to compare OCD with PG with the following research questions. 1) Is there a disorder in cognitive flexibility in OCD and PG groups measured with the WCST ) compared to the healthy control group? 2) Are there differences…
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcomes of the RLT
- number of correct responses with a reward
- number of probalistic errors with change of strategy
- number of probalistic errors without change of strategy
- number of spontaneous errors
- number of last reversal errors
- reaction time in seconds
Primary outcomes of the WCST:
- number of correct responses
- number of errors
- number of perseverant errors
- number of complete categories.
- Reaction time.
Secondary outcome
The secundary variables:
- Gender
- Age
- Marital status
- Level of education
- medication
- years of onset disease (in years)
- comobidity
The outcomes of the items from the Brief Symptom Inventory, Padua-Inventory and
the South Oaks Gamblingscale will measured as variables.
Background summary
Introduction: The behaviour in chronical addiction and pathological gambling (
PG ) shows similarities with obsessive compulsive disorders. As a result
addiction and PG could be rated among the obsessive - compulsive spectrum
disorders. Phenomenological similarities and differences are characterised by
having compulsions with OCD and impulses with PG. The distinction is made
because of the fact that compulsions are fear related and impulses are mainly
aimed at sensations and rewards. Compulsions and impulses may both have a
similar and abnormal regulation mechanism for overte stimuli, which will lead
to repetitive ( self - injuring ) actions. In the field of neuro - biology a
malfunction may be present in the orbito frontal cortex and gyrus cinguli.
These structures are associated with the inhibitory system
( regulation mechanism ). In this study two aspects of the regulation
mechanism are dealt with. The first aspect concerns the extent of sensitivity
to rewards and for this the Reversal Learning Task will be used. The second
aspect concerns the extent of cognitive flexibility. In order to look into
this the Wisconsin Card Sorting Test ( WCST ) is used. It appears from
literature that little research has been conducted into performances on RL task
and the WCST among PG and OCD clients. From the rare findings available appears
that to a variable extent disorders are found on both the RL task and the
WCST, during which the OCD and the PG group on average perform worse than the
control groups. As a result it seems likely that a disruption possibly has
taken place in the reward processes in which OCD and PG patients are aimed at
direct rewards and that the OFC striatal loops may be involved.
Study objective
The goal of our research is to compare OCD with PG with the following research
questions.
1) Is there a disorder in cognitive flexibility in OCD and PG groups measured
with the WCST ) compared to the healthy control group?
2) Are there differences between OCD and PG groups in reward related learning (
measured with the Reversal Learning Task ) compared to the healthy control
group?
Study design
Method: A comparative study is conducted in three groups: OCD, PG and a control
group. Use is made of DSM diagnoses already made by psychiatrists or
psychotherapists. Also the Brief Symptom Inventory is administered to survey
the co-morbidity. To support the diagnoses OCD and PG two self-reporting scales
are held, respectively the Padua Inventory-R and South Oaks Gambling Scale.
Then once only the RL task and the WCST will be held. The results are compared.
Study burden and risks
There are no risk and there are no direct benefits with participation of the
research. Total time will be 30 minutes.
Bethaniestraat 2
5211 LJ Den Bosch
NL
Bethaniestraat 2
5211 LJ Den Bosch
NL
Listed location countries
Age
Inclusion criteria
the most important inclusion criteria is the presence of obsessive compulsive disorder and pathological gambling
Exclusion criteria
The most important exclusion criteria is
colourblindness
One of the following diagnosis ADHD/ psychotic disorders/ manic episode
Neurological disorders ( epilepsia, CVA)
Drugs dependency
Recent drugsabuse <24 uur
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL28914.097.09 |