Our primary objective is to compare the changes in renal vascular resistance in 10 years between women with a history of preeclampsia and controls.
ID
Source
Brief title
Condition
- Maternal complications of labour and delivery
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Renal vascular resistance
Secondary outcome
Glomerular filtration rate (GFR), total peripheral vascular resistance (TPVR),
blood pressure, plasma volume, arterial and venous compliance and
cardiovascular morbidity.
Background summary
Preeclampsia is associated with an increased risk on the development of
cardiovascular and renal disease. It seems that similar risk factors are both
predictive for preeclampsia and cardiovascular disease. We hypothise that women
with a history of preeclampsia have accelerated vascular aging in comparison
with controls.
Study objective
Our primary objective is to compare the changes in renal vascular resistance in
10 years between women with a history of preeclampsia and controls.
Study design
Observational case-control study. A longitudinal study, based on a previous
study in the period of 1996-1999.
Study burden and risks
The introduction of two intravenous catheters may be painfull. In total 60 ml
of blood will be sampled. The infusion of the following solutes
(para-aminohippo acid, inuline, HSA) will rarely give an allergic reaction.
Plasmavolume measurement is done by albumin tagged with radioactive iodine,
which gives a low dose of radiation.
Universiteitssingel 50
Postbus 616, 6200 MD Maastricht
Nederland
Universiteitssingel 50
Postbus 616, 6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Inclusion of women who participated in a previous clinical study in the period of 1996-1999. Women with preeclampsia or HELLP syndrome in history and controls with a history of uncomplicated pregnancy.
Exclusion criteria
Preexistent hypertension (before pregnancy)
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | 5236 (NTR nummer volgt) |
| CCMO | NL26151.068.08 |