Our overall aim is to obtain a better understanding of brain network damage in dementia patients. We propose a research project with two key objectives:1. Develop improved methods to describe functional brain network damage2. Relate network damage…
ID
Source
Brief title
Condition
- Neurological disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Measures of functional connectivity; the synchronization likelihood and phase
lag index (these are quantitative variables derived by a mathematical procedure
using the original MEG signal).
Secondary outcome
Main network variables (described by graph theory applied to functional
connectivity measures of MEG recordings) between patients and controls; the
cluster coefficient (measure of local network structure) and the path length
(measure of global network structure)
MMSE score and outcomes of other neurological tests.
Background summary
One of the central questions in neuroscience is how brain networks are related
to cognitive function and, like in Alzheimer*s disease (AD), to cognitive
dysfunction. In order to solve this question, applying complex network theory
to neuroscience data is a new and promising approach. Recently, abnormal
structure of brain networks in dementia has been described. The cause and
clinical significance of this *network randomisation* are not yet understood.
Study objective
Our overall aim is to obtain a better understanding of brain network damage in
dementia patients. We propose a research project with two key objectives:
1. Develop improved methods to describe functional brain network damage
2. Relate network damage to clinical signs and disease course in dementia
Study design
a longitudinal magnetoencephalography (MEG) study; two times a MEG registration
with cognitive testing (duration around 2 hours total), separated by a year.
Study burden and risks
The MEG procedure is completely non-invasive, risks associated with
participation are negligible, and the burden can be considered minimal; it
consists of sitting quietly in a closed room for 30 minutes, which can be
aborted at any given time.
De Boelelaan 1118
1081 HZ Amsterdam
Nederland
De Boelelaan 1118
1081 HZ Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
For patients:
o Age between 18 and 85
o Minimal MMSE score of 18
o Recently diagnosed with *mild to moderate* Alzheimer*s disease or Frontotemporal dementia
o Written informed consent
For healthy controls:
o Age between 18 and 85
o Written toestemming
Exclusion criteria
For both patients and healthy controls:
o Other neurodegenerative or cerebrovascular disease
o Psychiatric disease or symptoms
o Insufficient mastery of the Dutch language
o Inability to communicate adequately.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL21588.029.08 |