To determine the estimation of prevalence of the primary research parameter for deficits in social cognition; e.g. facial emotion perception, after subarachnoid haemorrhage which has been treated through neurosurgical- (clipping) and/or endovascular…
ID
Source
Brief title
Condition
- Other condition
- Central nervous system vascular disorders
Synonym
Health condition
aneurysmatische subarachnoidale bloeding en neurochirurgische - (clippen) of endovasculaire interventie (coilen); stoornissen in sociale cognitie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Deficits in social cognition e.g. facial emotion perception based on scores on
the Facial Expressions and Emotions: Stimuli and Tests (FEEST; Young et al.,
2002) in the chronic stage (20months post SAH).
Secondary outcome
Scores on tests and questionnaires for social cognition and social functioning
in daily life in the subacute, chronic and stable endstage (4.5 months, 20
months and 4 years post SAH), being the Read The Mind in the Eye test (RTME;
Baron-Cohen et al., 1997), Cartoon test (Happé et al., 1999), Cartoon
prediction task (O* Sullivan & Guilford, 1965), Humourprocessing task
(Brownell, 1983), Faux Pas test (Stone et al.,1998), Social Attribution Task
(SAT; Klin, 2000), Iowa Gambling Task (IGT; Bechara, 1994), Sustained Attention
to Response Task (SART; Robertson et al., 1997), Test for Emotional Prosody
(Pijnenborg et al, 2007), The Awareness of Social Inferences Test (TASIT;
McDonald et al., 2003), Emotional Empathy Questionnaire (EEQ, Mehrabian &
Epstein, 1972), Questionnaire for emotional consequences of stroke (VEG,
Schure et al., 1995), Apathy Evaluation Scale (AES; Marin et al., 1991).
Scores on tests for memory, attention, mental speed and executive functioning
(WAIS digit span, 15WT, Stroop KW test, Trailmaking test, WTS S1-S3, DT,
Fluency, Zoo Map en DEX) and an estimated premorbid IQ based on the Dutch
version of the NART (NLV; Schmand et al., 1992).
Psychological and somatic complaints (SCL-90), personality questionnaire (NPV),
coping (UCL).
Background summary
Patients who experienced a subarachnoid haemorrhage (SAH) resulting from a
ruptured aneurysm and are subsequently treated with neurosurgical- (clippin) or
endovascular intervention (coiling) frequently report problems concerning
social and emotional functioning in daily life. These problems can indicate
deficits in social cognition which can manifest themselves as emotionally
indifferences, apathy, mood disorders, agitation, impulsivity, emotionally
disinhibited behaviour, emotional instability, problems in decisionmaking,
socially inadequate behaviour and problems in understanding or mentalising
other's thoughts, desires and feelings. These problems could partially be
caused by failure of psychological mechanisms and copingstyles with regard to
acceptance and adaptation to the traumatic event and possible cognitive
disturbances caused by brain damage. However, there is evidence that brain
damage can cause deficits in social cognition, especially following damage to
orbitofrontal/ventromedial prefrontal brain area's. Social cognition implies
the ability to perceive social information (i.e. facial expressions of
emotions), to integrate this information with general knowledge of social
schemes and conventions in order to understand the behaviour of others and to
correctly adapt ones behaviour to the social situation.
Such disturbances in social and emotional behaviour can have serious, adversive
consequences for SAH patients who, after a period of initial recovery, try to
go back to work and social life but disturbances in social cognition prevent
them from doing so. Deficits in social cognition are often seen in brain damage
especially when there is damage to orbitofrontal/ventromedial prefrontal brain
circuits. An aneurysm of the Anterior Communicating Artery is the most
frequent location of a SAH en disturbances in social cognition are expected
here. Besides the specific intervention (clip or coil) could play a role in
disturbances of social cognition. Social cognition has not been investigated in
SAH patients while there is evidence that changes in emotion and behaviour are
permanent. However, until now ther were no adequate neuropsychological tests to
measure social cognition in brain damaged people. In our clinical pilot we
developed a state-of-the-art testset for social cognition to measure all
different aspects of social cognition in SAH patients. These supplementary
tests for social cognition are necessary in regular neuropsychological
diagnostics to measure deficits in social cognition and to develop treatment
possibilities in the future. Because of the relatively young age of SAH
patients (mean 55 years), these deficits in social cognition can have serious,
adverse consequences for the ability of patients to funtion adequately in daily
life, that is engage in social relationships and maintain a job.
Study objective
To determine the estimation of prevalence of the primary research parameter for
deficits in social cognition; e.g. facial emotion perception, after
subarachnoid haemorrhage which has been treated through neurosurgical-
(clipping) and/or endovascular intervention (coiling). And also to determine
the estimated prevalence of the secundary research parameters for deficits in
social cognition and general cognition in these patients related to the primary
research parameter.
Study design
A study of 150 patients who suffered from subarachnoid haemorrhage and received
treatment through neurosurgical- (clipping) and/or endovascular intervention
(coiling) in a repeated measures design (4.5 months, 20 months and 4 years post
SAB) to investigate the prevalence of deficits in social cognition in the
subacute, chronic and stable endstage post SAH.
Study burden and risks
This research project will have no risks for the patients involved. The
neuropsychological investigation will have no adverse consequences for the
patients. The burden is minor and mainly mentally, especially when patients are
confrontated with neuropsychological impairments during testing. However, this
will be carefully monitored and coached by the neuropsychologist who has ample
experience with patients suffering from acquired brain injury.
UMCG, Hanzeplein 1
9713 GZ Groningen
NL
UMCG, Hanzeplein 1
9713 GZ Groningen
NL
Listed location countries
Age
Inclusion criteria
1) subarachnoid haemorrhage, no intervention, neurosurgical (clipping) and/or endovascular intervention (coiling)
Exclusion criteria
1) neurodegenerative of psychiatric disorders
2) severe cognitive comorbidity interfering with the ability to understand test instructions and undergo neuropsychological tests (global aphasia, neglect, amnestic syndrome)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL25822.042.09 |