In this study we will be looking at the effects of the different administration routes on release of satiety hormones by the small intestine.
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will be looking at the secreted satiety hormones by the biops. We will be
looking at CCK, GLP-1, and PYY. We will also look at the hunger and satiety
ratings of the subjects
Secondary outcome
-
Background summary
Food in the small intestine stimulates intestinal cells to secrete satiety
hormones. These satiety hormones regulate the feeling of hunger and food
intake. Little is known about the effects of different administration routes on
the release of satiety hormones.
Study objective
In this study we will be looking at the effects of the different administration
routes on release of satiety hormones by the small intestine.
Study design
During the first 4 testdays, subject will receive protein or placebo, either
oral or intraduodenal administered. On the testdays with oral administration,
samples will be taken from the intestinal fluid. Bloodsamples will also be
taken. On the last testday, biopsies are taken from the subjects. The tisue is
than kept alive for approximately 4 hours. As an optional testdag, biopsies are
taken again from the subjects.
Intervention
During the first 4 testdays, subject will receive protein or placebo, either
oral or intraduodenal administered. On the testdays with oral administration,
samples will be taken from the intestinal fluid. Bloodsamples will also be
taken. On the last testday, biopsies are taken from the subjects.
Study burden and risks
A hematome can develop after placing the canula. There is a small chance that
intestinal perforation may occur. The test subject can experience some
discomfort when the gastroscope is inserted.
P.O. Box 616
6200 MD Maastricht
Nederland
P.O. Box 616
6200 MD Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
• Male, non smoking
• Age between 18 and 65 years
• Body Mass Index between 20 and 37 kg/m2
• No medication that could interfere with the test results (e.g. glucose lowering medication)
• No history of intestinal illness
• Stable body weight over the last three months
Exclusion criteria
• Age under 18 and over 65 years
• BMI under 20 and over 37 kg/m2
• Medication or disease that could interfere with the results of the study, to be judged by the responsible medical doctor
• Recent blood donation
• Intestinal illness at any time in the past
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24018.068.08 |
| Other | NTC1437 |