To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
ID
Source
Brief title
Condition
- Autoimmune disorders
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Not applicable
Secondary outcome
Not applicable
Background summary
5 mm skin bopsies, taken from non-involved skin of a psoriasis patient
(volunteer), are transplanted onto immune-deficient mice . They are then
injected with white blood cells from the same volunteer to induce the
develpoment of a psoriatic lesion in the transplant. A number of standard
drugs have been shown to inhibit development of the psoriatic lesion, showing
that the model is suitable for developing new drugs for treating psoriasis.
Client wishes to test a novel drug in the transplant model.
Study objective
To see if the new drug can prevent development of psoriatic changes in the
transplant model of psoriasis
Study design
3x5 mm skin biopsies and 27 ml blood will be taken from non-involved skin of 10
psoriasis patient (volunteer). The biopsy sites will be closed using 1 stitch.
After 1 week the stitches will be removed. These materials will be used in the
transplant model of psoriasis to test the new drug.
Study burden and risks
The transplant model of psoriasis used is the only in vivo one available for
evaluating the probable efficacy of new drugs to treat psoriasis. Donating skin
biopsies is not percieved as being painful or taxing by the volunteers and they
do not result in significant scarring. Donors consider the potential benifits
in developing new therapies to more than compensate for any discomfort.
Sudbrackstraße 56
D-33611 Bielefeld
DE
Sudbrackstraße 56
D-33611 Bielefeld
DE
Listed location countries
Age
Inclusion criteria
Mild to moderate psoriasis vulgaris
Exclusion criteria
Volunteers can not be taking drugs systemically, including immune-modifiers for other diseases.
Volunteers cannot be be undergoing UV/light therapy
Volunteers should not show Kobner phenomenon at wound sites.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32436.098.10 |