To see if the new drug can prevent development of psoriatic changes in the transplant model of psoriasis
ID
Source
Brief title
Condition
- Autoimmune disorders
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
NVT
Secondary outcome
NVT
Background summary
5 mm skin bopsies, taken from non-involved skin of a psoriasis patient
(volunteer), are transplanted onto immune-deficient
mice . They are then injected with white blood cells from the same volunteer to
induce the develpoment of a psoriatic
lesion in the transplant. A number of standard drugs have been shown to inhibit
development of the psoriatic lesion,
showing that the model is suitable for developing new drugs for treating
psoriasis. Client wishes to test a novel drug in the
transplant model.
Study objective
To see if the new drug can prevent development of psoriatic changes in the
transplant model of psoriasis
Study design
3x5 mm skin biopsies and 27 ml blood will be taken from non-involved skin of 10
psoriasis patient (volunteer). The biopsy
sites will be closed using 1 stitch. After 1 week the stitches will be removed.
These materials will be used in the transplant
model of psoriasis to test the new drug.
Study burden and risks
The transplant model of psoriasis used is the only in vivo one available for
evaluating the probable efficacy of new drugs
to treat psoriasis. Donating skin biopsies is not percieved as being painful or
taxing by the volunteers and they do not
result in significant scarring. Donors consider the potential benifits in
developing new therapies to more than compensate
for any discomfort.
Technologiepark 30
9052 Zwijnaarde
BE
Technologiepark 30
9052 Zwijnaarde
BE
Listed location countries
Age
Inclusion criteria
Mild to moderate psoriasis vulgaris
Exclusion criteria
Volunteers can not be taking drugs systemically, including immune-modifiers for other diseases.
Volunteers cannot be be undergoing UV/light therapy
Volunteers should not show Kobner phenomenon at wound sites.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL33124.098.10 |