The present proposal comprises the combination of aforementioned techniques to study reflex modulation by the CNS of peripheral reflexes. The influence of careful timed TMS pulses on the contralateral sensorimotor cortex of healthy subjects on EMG…
ID
Source
Brief title
Condition
- Movement disorders (incl parkinsonism)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome parameter is the amplitude of the M2 response as assessed by
EMG activity. Dependents are characteristics of ramp-and-hold stretches and
timed TMS pulses. Repeated measures Analysis of Variance will be applied for
statistical analysis. Statistical significant differences of 30% in normalized
M2 amplitude will confirm CNS modulation of peripheral reflex activity.
Secondary outcome
nvt
Background summary
Humans have the ability to adjust their reflexes according to the environmental
conditions and task to perform. Modulation of reflexes is paramount for optimal
movement in daily life. In central neurological like diseases like stroke,
inability to modulate reflexes may be the cause for the observed movement
disorders. Therefore it is of importance to understand if and how the central
nervous system (CNS) modulates peripheral reflexes. Peripheral reflex activity
can be assessed by stretch reflexes of the m. flexor carpi radialis evoked by a
wrist manipulandum and measured by EMG (electromyography). EMG results in
typical short (M1) and long latency (M2) reflex bursts. CNS activity can be
evoked by Transcranial Magnetic Stimulation (TMS).
Study objective
The present proposal comprises the combination of aforementioned techniques to
study reflex modulation by the CNS of peripheral reflexes. The influence of
careful timed TMS pulses on the contralateral sensorimotor cortex of healthy
subjects on EMG activity evoked by motorized stretches of the m. flexor carpi
radialis is investigated.
Study design
N=10 healthy subjects will be included to participate in the present
experiment. Total experimental time will be 3 hours. Subjects are asked to
exert low flexion torques around the wrist, while ramp-and-hold stretches with
a fixed velocity of 1,5 rad/s and various stretch durations (30-70 ms) are
imposed by a wrist manipulandum. Simultaneous and variable timed sub threshold
single pulse TMS is imposed. Burden and risks for the subjects is minimal,
because of small perturbation amplitude and subthreshold TMS single pulses.
Subjects with any history of epilepsy will be excluded.
Study burden and risks
The burden for the subject involved is restrained to holding a flexion force
with the wrist repeatedly. Sufficiënt rest will be allowed to prevent fatigue.
The Transcranial Magnetic Stimulation is applied in a very low frequency with
subthreshold intensity and therefore has a very low burden and risk level.
Postbus 9600
2300 RC Leiden
NL
Postbus 9600
2300 RC Leiden
NL
Listed location countries
Age
Inclusion criteria
- Age between 40-70
Exclusion criteria
cardiac pacemakers; any metal implant within the brain;any medical history of general and local neurological disorders, especially epilepsy; any history of orthopedic problems with the upper extremities; current medication that may influence nervous function.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL33936.058.10 |