Primary endpoint:Measuring lymphocyte response in patients with suspected pulmonary bird fanciers lung by ELISPOT technique.
ID
Source
Brief title
Condition
- Allergic conditions
- Lower respiratory tract disorders (excl obstruction and infection)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Measuring the ELISPOT response to cells obtained from BAL fluid in patients
with clinically strong suspicion " bird fancier lung"
Secondary outcome
not applicable
Background summary
From previous studies in patients with active pulmonary tuberculosis shows that
the lymphoid cells in the BAL fluid present strongly react to
tuberculosis specific antigens.This makes the researchers want to be seen
whether the same phenomenon occurs in pigeon fanciers lung.
Bird fancier's lung is a so called extrinsic allegic alveolitis. Characteristic
for this deviation is a greatly increased number of lymphocytes in BAL fluid.
In one patient we already demonstrated this hypothesis to be feasible.
Study objective
Primary endpoint:
Measuring lymphocyte response in patients with suspected pulmonary bird
fanciers lung by ELISPOT technique.
Study design
Pilotstudy:
10 of pigeon fanciers lung disease suspected patients and 10 patients who have
to undergo a bronchoscopy with BAL for other reasons.
Open study, laboratory assays (ELISPOT and precipitines) will be blinded.
Study burden and risks
Bronchoscopy is relatively easily to undergo. There seems to be a relationship
between age and tax to exist.
There is a risk for fever, infection and bleeding after bronchoscopy with
bronchoalveolar lavage.
Bosboomstraat 1
3508 TG Utrecht
NL
Bosboomstraat 1
3508 TG Utrecht
NL
Listed location countries
Age
Inclusion criteria
All patients with suspicion of pigeon induced bird fancier's lung.
Exclusion criteria
Patients < 18 years and mentally impaired patients
Patients who use corticosteroids or other immunsupressive for the bronchoscopie.
Patients who can't read and sign the informed consent.
Patients in who BAL is technically impossible or contraindicated
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| ClinicalTrials.gov | NCT01237145 |
| CCMO | NL33463.075.10 |