The key objectives of this study is to examine i) the neural correlates of social interactions with peers, ii) to examine the development of these neural patterns across adolescence, and iii) to focus on their links with psychosocial adjustment.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Geen aandoening!! Onderzoek naar gezonde hersenontwikkeling, hersenfunctie, hersenstructuur en gedrag
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. Behavior as assessed by computer tasks on decision-making
2. Functional MRI to gain information on task-related brain activity during
decision-making
3. Structural MRI, to gain information on gray and white matter properties
4. DTI, to gain specific information on white matter microstructure and
fibertracking
Secondary outcome
Problem behavior levels and psychosocial functioning (depressive symptoms and
scores on the Child Behavior Checklist)
Background summary
The formation and maintenance of peer relationships is one of the most
important developmental tasks across adolescence. During this period peer
relationships become more diverse and complex. The current project aims to
study the neural mechanisms underlying social interactions with peers across
adolescence. We will examine various aspects of social interactions, such as
fairness, trust and reciprocity, and helping, with different relationship
partners, namely positive peers (friends), negative peers (antagonists), and
neutral classmates as well as anonymous (not personally known) peers. The
proposed innovative approach will not only help to examine neural mechanisms
involved in peer relationships across adolescence, but will also provide us
with insights into the role of brain development in links between positive
interactions with peers and psychosocial adjustment.
Study objective
The key objectives of this study is to examine i) the neural correlates of
social interactions with peers, ii) to examine the development of these neural
patterns across adolescence, and iii) to focus on their links with psychosocial
adjustment.
Study design
This study uses an experimental design. Participants will perform computerized
decision-making tasks and we will measure brain activation using functional
Magnetic Resonance Imaging (fMRI) while they are performing the tasks.
Study burden and risks
There are no known risks associated with participating in an fMRI study. (see
also p. 29-30)
This is a noninvasive technique involving no catheterizations or introduction
of exogenous tracers. Numerous children and adults have undergone magnetic
resonance studies without apparent harmful consequences. Some people become
claustrophobic while inside the magnet and in these cases the study will be
terminated immediately at the subject's request. The only absolute
contraindications to MRI studies are the presence of intracranial or
intraocular metal, or a pacemaker. Relative contraindications include pregnancy
and claustrophobia. Subjects who may be pregnant, who may have metallic foreign
bodies in the eyes or head, or who have cardiac pacemakers will be excluded
because of potential contraindications of MRI in such subjects. Although there
is no direct benefit to the participants from this proposed research, there are
greater benefits to society from the potential knowledge gained from this
study. This knowledge about normal development is critical to aid in the
understanding of cases of abnormal development, as seen in children with
autism, schizophrenia, Attention Deficit Hyperactivity Disorder,
Obsessive-Compulsive Disorder, Tourette*s syndrome, or traumatic brain injury.
Postbus 9555
2300RB Leiden
NL
Postbus 9555
2300RB Leiden
NL
Listed location countries
Age
Inclusion criteria
See also page 21 in the protocol
1. Healthy children, adolescents and young adults without a history of neurological disorders
2. Right-handedness
3. No counter-indications for MRI
4. Native Dutch speakers
Exclusion criteria
1. Left-handedness
2. A history of psychiatric and/or neurological disorders
3. Counter-indications for MRI (such as metal implants, heart arrhythmia, claustrophobia and possible pregnancy)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34045.058.10 |