The primary objective of this current proposal is to test validity of the MPH test to detect DH. Validity is analyzed by comparing MPH-induced DH with DH induced by a symptom-limited incremental cycle exercise test.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The change in IC after MPH and exercise: MPH- and exercise- induced DH.
Secondary outcome
not applicable
Background summary
During exercise in COPD patients, air trapping causes an increase in end
expiratory lung volume (EELV) and a decrease in inspiratory capacity (IC). This
is called dynamic hyperinflation (DH) and is determined by measuring the IC
before and during exercise. Various studies have used symptom-limited
incremental cycle ergometry to detect DH. Because this method to determine DH
is relative expensive, time consuming and uncomfortable for patients, new
methods have been sought. DH induced by metronome-paced hyperventilation (MPH)
for 20 seconds at twice the resting respiratory rate was compared to DH induced
by cycle ergometry in patients with COPD and a similar significant decrease in
IC was found. However, this has never been confirmed by other investigators.
Currently, the repeatability and validity of the MPH test is studied in COPD
patients by our research group (CMO dossier nr: 2008/322, ABR nr:
NL25920.091.08). However, it is unknown whether the MPH test can discriminate
between hyperinflators and non-hyperinflators. Therefore, also age-matched
healthy volunteers are needed. The hypothesis is that these healthy subjects
are not susceptible to DH, and therefore do not show a decrease in IC during
the exercise test, nor after MPH.
Study objective
The primary objective of this current proposal is to test validity of the MPH
test to detect DH. Validity is analyzed by comparing MPH-induced DH with DH
induced by a symptom-limited incremental cycle exercise test.
Study design
This study is an instrumental study, because it evaluates the MPH test. The
healthy subjects perform lung function testing, the MPH test and a
symptom-limited incremental cycle exercise test.
Study burden and risks
In case of participation, all tests for one subject are planned on one day with
a maximal span of two hours. The healthy subjects themselves do not benefit
from the study. However, by including healthy subjects, the MPH-test can be
validated providing a new, more easy tool to detect DH. Because subjects are
asked to cycle with increasing load until their maximal exercise capacity is
reached, there is a risk of unknown underlying cardiac problems becoming overt.
Therefore, this test is always supervised by qualified, experienced personnel.
Nijmeegsebaan 31
6561 KE Groesbeek
NL
Nijmeegsebaan 31
6561 KE Groesbeek
NL
Listed location countries
Age
Inclusion criteria
Non-smoking capable subjects, aged 50-75 years, with a FEV1/VC ratio (forced expiratory volume in one second divided by the vital capacity) > 0.7 and FEV1 >= 80% of predicted
Exclusion criteria
Subjects with asthma history or with lung problems of any kind, or with severe exercise limiting cardiac or neuromuscular disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32779.091.10 |