Objectives: 1) Describe the course of muscle SrO2 in patients with severe sepsis in relation to outcome and severity of disease 2) Describe the relationship between muscle SrO2 and serum lactate, SvO2, DO2 and VO23) Describe the course of cerebral…
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameters/endpoints: Primary endpoints will be delirium and the
correlation between SrO2 and SvO2.
Secondary outcome
Secondary endpoints will be duration of reversal of sepsis, mortality, duration
of ICU stay, duration of hospital admittance and duration of mechanical
ventilation.
Background summary
The true endpoint of resuscitation in intensive care medicine is maintenance of
aerobic circulation. This almost philosophical goal is hard to measure. So far,
measurement of local perfusion by infrared camera is as close as one can get,
but measurement of tissue oxygenation is the next step. This protocol describes
the possibilities of testing the measurement of tissue oxygenation in muscle
and brain in patients with severe sepsis.
Study objective
Objectives:
1) Describe the course of muscle SrO2 in patients with severe sepsis in
relation to outcome and severity of disease
2) Describe the relationship between muscle SrO2 and serum lactate, SvO2, DO2
and VO2
3) Describe the course of cerebral SrO2 during the course of severe sepsis
4) Describe the relationship between cerebral SrO2 in patients with severe
sepsis and delirium
Study design
Study design: An observational single center pilot study.
Study burden and risks
The only burden for the participant consists of 2 electrodes being placed on
the head and 1 on the arm. The only theoretical risk is an allergic reaction to
the INVOS electrode. There is no clear benefit for the included patients of
this study.
Bosboomstraat 1
3582 KE Utrecht
NL
Bosboomstraat 1
3582 KE Utrecht
NL
Listed location countries
Age
Inclusion criteria
age >=18
severe sepsis( 2 SIRS criteria plus focus of infection) and organ failure
written informed consent
Picco guided resuscitation
Exclusion criteria
Terminal phase of disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32009.100.10 |
| Other | NL32009.100.10 |