Measuring specific antibody titers against influenza A (subtype H1N1 and / or seasonal vaccine) in DS children. DS anti-influenza antibody titers will be compared with controls available from the same laboratory.
ID
Source
Brief title
Condition
- Immunodeficiency syndromes
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Specific anti-influenza A (subtype H1N1 and / or seasonal) antibody titers will
be measured.
Secondary outcome
not applicable.
Background summary
Children with Down syndrome show an increased incidence of infections and
auto-immune diseases. Past publications have already increased the general
knowledge on the DS immune system. Assaying specific antibody production
against influenza A (subtype H1N1 and seasonal) can be used as a model to
assess T-cell dependent (anti-protein) antibody responses can be used to
further increase this knowledge. Over the course of the last quarter of 2009
influenza A vaccinations have been given to risk groups on a global scale,
including several Dutch DS children.
Study objective
Measuring specific antibody titers against influenza A (subtype H1N1 and / or
seasonal vaccine) in DS children. DS anti-influenza antibody titers will be
compared with controls available from the same laboratory.
Study design
This is an observational study. At the time of a medically indicated regular
venepuncture, 5 ml of extra blood will be drawn for study purposes.
Study burden and risks
Patients will not directly benefit from participating in this study. The burden
involved is limited due to the fact that patients will not need to undergo an
extra venepuncture. The expected increase of knowledge about the DS immune
system outweighs the limited burden imposed on patients participating in this
study.
Nieuwstraat 34
5211 NL 's-Hertogenbosch
NL
Nieuwstraat 34
5211 NL 's-Hertogenbosch
NL
Listed location countries
Age
Inclusion criteria
down syndrome
vaccination with Influenza A
Exclusion criteria
immunodeficiency other than down syndrome
recent infections prior to blood sample collection
treatment with immunosuppressive drugs in last year prior to blood collection
history of oncological disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32172.028.10 |