Evaluation of effect of fluidrescucitation on sublingual microcirculation by SDF imaging in Intensive Care patients, a pilot study

Although we do al lot of measurments to monitor the fluidstate of the patients,
we don't know exactly weather the fluid has real effect on the organ perfusion.
The main focus of fluid is to improve the organ perfusion. Recent research has
focused on the investigation of sublingual microcirculatory alterations.

Objective: Is fluid responsiveness, what means a better cardiac output, equal
to the need for fluid for a better organ perfusion?
In hospital we now looking to the pumpfunction of the heart, we don't have a
better measurement. However this gives no information about necesity of giving
fluids.. A healthy volunteer also gives a better pumpfunction of the heart
after fluid, but that fluid is not necessary and gives no better organperfusion.
The question is: Howmany percent of the patients have a MFI score of < 2.6 when
the doctor on clinical basis plans to give fluid to the patient. Improves organ
perfusion after fluid and is this correlated with an improvement of the cardiac
output

All intensive care patients who need extra fluid are eligible for this stduy.
Before and after the fluid challenge we do SDF imaging sublingual. Per patient
we do this 1x in 24 hours.
Concurrently, data on both patient characteristics (e.g. severity of illness)
will be obtained
Studypopulation max 100 patients.

Possible outcome:
MFI < 2,6 en SV > 10% + MFI up
MFI < 2,6 en SV gelijk + MFI equal
MFI < 2,6 en SV > 10% + MFI equal
MFI < 2,6 en SV gelijk + MFI up
MFI > 2,6 en SV > 10% + MFI up
MFI > 2,6 en SV gelijk + MFI equal
MFI > 2,6 en SV > 10% + MFI equal
MFI > 2,6 en SV gelijk + MFI up

Non invasive measurement, no damaging consequences have been observed