The present study intends to perform functional magnetic resonance imaging (fMRI) in order to obtain further insight in effects of selective attention on sensory processing. This study aims to compare subjects with normal hearing to patients that…
ID
Source
Brief title
Condition
- Hearing disorders
- Neurological disorders NEC
- Disturbances in thinking and perception
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Audiometric and psychometric values obtained by means of questionnaires and
audiological exams, parameters related to task performance and stimulus-evoked
BOLD fMRI signals in the brain.
Secondary outcome
not applicable
Background summary
Tinnitus is a prevalent hearing disorder that affects millions of people and
has a severely disabling impact on life in about 1-3% of the general
population. It is characterized by the perception of sound in the absence of
any external sound sources. Attention deficit is part of the psychopathological
profile of tinnitus patients, which have difficulty to focus on task
performance. Whether this deficiency is maintained across sensory modalities or
is mainly present within the auditory domain remains unclear. This study aims
to achieve further knowledge on the neural correlates of the pathophysiology of
this condition. Neuroimaging studies on tinnitus rarely address activity in
higher brain areas, beyond the classical auditory brain centers. In particular,
neuroimaging studies on attention and tinnitus have never been carried out.
Study objective
The present study intends to perform functional magnetic resonance imaging
(fMRI) in order to obtain further insight in effects of selective attention on
sensory processing. This study aims to compare subjects with normal hearing to
patients that suffer from tinnitus.The effects of distractors on task
performance will be assessed. We will determine brain areas and networks
involved in auditory and visual perception and compare their function in the
presence or absence of distractor stimuli in the other modality. In addition to
such cross-modal effects, we will also assess unimodal effects by studying
sound-evoked responses in the presence or absence of distractor auditory
stimuli (i.e., in the same modality). This will be approached through
neuroimaging methods allowing access to functional interactions between higher
and lower brain areas (e.g. related to attention and audition, respectively).
Study design
Two-group exploratory study.
Study burden and risks
The audiological and psychometric assessment involve several audiometric tests,
and the administration of questionnaires (approx. 2 hours). Two fMRI scanning
sessions will take place on separate days (approx. 1 hour each). None of the
procedures expose the subject to known risks or major burden.
P.O. Box 30.001
9700 RB Groningen
NL
P.O. Box 30.001
9700 RB Groningen
NL
Listed location countries
Age
Inclusion criteria
Patient group:
Report of mild to moderate subjective tinnitus, characterized by a score of 18-56 on the Tinnitus Handicap Inventory;
No reported medical, neurological, or psychiatric disorders (excluding tinnitus);
Adult, 18-60 years of age;
Normal hearing thresholds or mild hearing loss (average threshold <60 dB @ 500-2000 Hz);
Symmetrical hearing thresholds (<20 dB difference between both ears for all frequencies);
No contraindications for fMRI according to the MRI-checklist; ;In healthy group:
Healthy subjects (i.e., no medical, neurological, or psychiatric disorders);
Adult, 18-60 years of age;
Normal hearing thresholds or mild hearing loss (average threshold <60 dB @ 500-2000 Hz);
Symmetrical hearing thresholds (<20 dB difference between both ears for all frequencies);
No contraindications for fMRI according to the MRI-checklist;
Exclusion criteria
Non-conformance with any of the inclusion criteria.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL33326.042.10 |