Is there a better way to detect REM sleep atonia than with the current visual analysis of submental muscle EMG? To which degree do muscles become atonic during REM sleep? Which muscle exhibit the largest decrease? How can this decrease best be…
ID
Source
Brief title
Condition
- Sleep disturbances (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
EMG-activity of various muscles in relation to sleep stage.
Secondary outcome
Not applicable
Background summary
Currently sleep protocols emphasize the use of electromyography (EMG) of
submental muscles to establish rapid eye movement (REM) sleep, during which
muscle tone is supposed to be very low. Unfortunately, in clinical practice the
decrease of submental EMG activity is often not clear enough to contribute to
scoring of REM sleep. The publications suggesting the submental muscle date
from the 1960's and did not conform to current standards of scientific
methodology. The purpose of this study is to reassess the decrease of muscle
tone during REM sleep and to improve its detection.
Study objective
Is there a better way to detect REM sleep atonia than with the current visual
analysis of submental muscle EMG? To which degree do muscles become atonic
during REM sleep? Which muscle exhibit the largest decrease? How can this
decrease best be measured? Can this muscle tone be helpful in the
identification of REM sleep?
Study design
Single center, observational study.
Study burden and risks
The volunteers will be asked to stay overnight in the hospital to undergo
polysomnography with additional electrodes. The procedure is painless and
basically takes time and an extra hair wash only.
Albinusdreef 2
2333 ZA Leiden
NL
Albinusdreef 2
2333 ZA Leiden
NL
Listed location countries
Age
Inclusion criteria
Healthy, 18-55 years old
Exclusion criteria
Age under 18 or above 55 years, relevant neurological or psychiatric disease, use of hypnotics or other drugs that affect muscle tone, the EEG or the sleep-wake cycle
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34543.058.10 |