To investigate the relation between different autonomic function tests in critically ill patients.
ID
Source
Brief title
Condition
- Ancillary infectious topics
- Peripheral neuropathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1) Correlation between the heart rate variability, cold face test and skin
wrinkle test results using Spearman*s rho
Secondary outcome
1) Timeline of changes in autonomic nervous system parameters in relation to
organ failure
2) Correlation between different autonomic nervous system parameters like heart
rate variability, the cold face test and the skin wrinkle test in different
groups of critically ill patients
Background summary
Autonomic nervous dysfunction is frequent in patients with multiple organ
dysfunction syndrome (MODS) and is associated with increased mortality. The
autonomic nervous system plays in important part in non-linear systems of the
body maintaining homeostasis by supplying organ to organ communication and
modulation.
Study objective
To investigate the relation between different autonomic function tests in
critically ill patients.
Study design
Prospective observational cohort pilot study
Study burden and risks
The role of autonomic function in patients with MODS can only be investigated
in the intensive care. For this study the autonomic nervous function is
assessed with tests that, with proper safety requirements, pose no to a
negligible risk to the patient. Though the patients under study will not
benefit from this study, the results of this study can ultimately lead to
better understanding and treatment of MODS.
Meibergdreef 9
Postbus 22700, 1100 DE Amsterdam
NL
Meibergdreef 9
Postbus 22700, 1100 DE Amsterdam
NL
Listed location countries
Age
Inclusion criteria
expected >3 days on mechanical ventilation
Exclusion criteria
Stroke as reason for admission, quadriplegia due to spinal cord disorder, neuromuscular disorder as reason for admission, patients with documented polyneuropathy or autonomic neuropathy in medical history
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL34849.018.10 |