To find out the fate of aneuploid blastomeres
ID
Source
Brief title
Condition
- Chromosomal abnormalities, gene alterations and gene variants
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The fate of aneuploid blastomeres
Secondary outcome
Endpoints of this study are the difference in cleavage rate, location and
transcriptome profile between euploid and aneuploid blastomeres within human
preimplantation embryos.
Background summary
The majority (78%) of human preimplantation embryos analyzed after in vitro
fertilization contain aneuploidies i.e. numerical chromosomal abnormalities.
Fifty-nine percent of human preimplantation embryos analyzed after in vitro
fertilization consist of both normal and aneuploid blastomeres. In contrast,
aneuploid rates in human fetuses and live births are extremely low, <3% and
0.6% respectively. This suggests that there is a selection against or
correction of aneuploid blastomeres during development. This study aims to
investigate the fate of aneuploid blastomeres within human preimplantation
embryos and the mechanisms that lead to decreased aneuploid rates further in
development.
Study objective
To find out the fate of aneuploid blastomeres
Study design
Observational study
Study burden and risks
Only left over, cryopreserved embryos are used for this study. These embryos
would be otherwise discarded. The couples that donated these embryos have
already finished their treatment or fulfilled their childbearing wish. The
couples have already given written consent for the use of their left over and
cryopreserved embryos for research purposes. No additional involvement is
required for the couples therefore no burden, risk or benefit is associated
with this study.
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Inclusion criteria
All left over, cryopreserved embryos that were donated with written consent from patients that underwent an IVF/ICSI treatment at the Academic Medical Center (AMC) that survive the thawing procedure.
Exclusion criteria
NA
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32157.000.10 |