To evaluate if 11C-PiB is able to detect amyloid deposits in affected other organs and tissues in patients with systemic amyloidosis and to correlate the uptake of 11C-PiB in the different organs to laboratory parameters, biopsies and other imaging…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
amyloidose (eiwitstapelingen) in diverse organen en weefsels
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Uptake of 11C-PiB in organs known with amyloid depositions.
Secondary outcome
Not applicable.
Background summary
Amyloidosis is a disease characterized by deposition of amyloid in organs and
tissues. For specific evaluation of systemic amyloidosis, serum amyloid P
component (SAP) scintigraphy is extensively used. However for brain and cardiac
involvement, 123I-SAP is not useful. In the brain, the PET tracer 11C-Pittsburg
compound B (PiB) is used with good results for imaging amyloid in Alzheimers
disease.
Study objective
To evaluate if 11C-PiB is able to detect amyloid deposits in affected other
organs and tissues in patients with systemic amyloidosis and to correlate the
uptake of 11C-PiB in the different organs to laboratory parameters, biopsies
and other imaging studies.
Study design
A pilot study of 10 patients will be performed to evaluate if 11C-PiB is able
to detect amyloid deposits in affected other organs and tissues. The
11C-PiB-PET scans will be evaluated qualitatively and quantitatively and
correlated to other parameters. If 11C-PiB-PET scan is proved to be useful,
larger studies with more patients will be performed.
Study burden and risks
Risk of a bruise or hematoma because of the infuse.
No side-effects expected.
The effective radiation dose will be 3.4 mSv per patient.
Hanzeplein 1
9700 RB Groningen
NL
Hanzeplein 1
9700 RB Groningen
NL
Listed location countries
Age
Inclusion criteria
Patients known with systemic amyloidosis with known amyloid deposits in various organs
Exclusion criteria
Patients < 18 years, pregnant or lactating women, and patients with claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32567.042.10 |