- To confirm findings in previous studies regarding the loss of functioning motor units in the first day after acute stroke. - To study peripheral nervous system excitability in order to be able to formulate a more detailed hypothesis regarding the…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
For neurophysiology: estimates of the number of functioning motor units (MUNEs)
and excitability variables obtained with threshold tracking techniques. For
clinical stroke assessment: questionnaires (NIHSS) and scales (modified Rankin
scale, Barthel index), CT, the TOAST classification of stroke subtype, and an
evaluation of cardiovascular risk factors.
Secondary outcome
N.v.t.
Background summary
Stroke often results in loss of motor function. An obvious explanation for this
loss is that the muscles that were under the control of the lesioned part of
the central nervous system can no longer be activated voluntarily. However,
several recent studies suggest that external stimulation of the peripheral
nervous system also elicits a diminished response from affected muscles. These
changes appear to occur within 24 hours following the stroke. This surprising
finding suggests that the function of the peripheral nervous system itself
becomes impaired, primarily with respect to its (in)ability to conduct
electrical signals.
Study objective
- To confirm findings in previous studies regarding the loss of functioning
motor units in the first day after acute stroke.
- To study peripheral nervous system excitability in order to be able to
formulate a more detailed hypothesis regarding the causes of this loss (if
present)
- To assess whether the onset and progression of electrophysiological
abnormalities are related to functional outcome and may, hence, potentially be
used as prognostic factors.
Study design
In this prospective study, patients with acute ischemic stroke will be
evaluated with neurophysiological and clinical tests. Measurements will be
performed six times between stroke onset (within 24 hours) and six months
later.
Study burden and risks
The investigations are non-invasive. There are no risks. The patients do not
gain any direct benefit from the study.
's-Gravendijkwal 230
3015 CE Rotterdam
NL
's-Gravendijkwal 230
3015 CE Rotterdam
NL
Listed location countries
Age
Inclusion criteria
- A first-ever ischemic stroke
- Hemiplegia, including weakness of the hand muscles
- Stroke onset < 24 hours before the first recordings
- Stable vital signs
Exclusion criteria
- Non stroke-related sensory or motor impairments
- Any peripheral lesion of the median nerve, such as nerve root compression syndrome, cervical spondylosis, carpal tunnel syndrome, or other peripheral neuropathy revealed by neurological examinations and electrodiagnostic tests
- Any history of other diseases or treatment that might have affected the peripheral nerve
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30323.078.09 |