1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Lipid metabolism disorders
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
microvascular function (structural by number of baseline capillaries and
functional by %recruitment after arterial occlusion using capillary microscopy)
Secondary outcome
early signs of atheroscleroses (by IMThickness and distensibility in the
carotis using ArtLab echografie)
markers of endothelial dysfunction and low grade inflammation (using blood
samples and elisa)
current glucose tolerance status starting with a one-touch glucose measurement
and 3 serum samples at start, afetr 1hr and after 2hrs (an OGTT)
Anthropometry: Length, weight and WHratio, skinfolds, whole-body DXA scan,
using standard techniques
Blood pressure, Systolic and diastolic pressures measured in triplicate in
sitting position using in the left upper arm at 5-minute intervals with an
oscillometric device
Questionnaires: Time/date of measurement, menses. current medication, SES, work
status, physical activity, smoking, alcohol, nutrition and mental well-being.
Background summary
A disturbed structure and function of the small vessels in the human body (i.e.
the microcirculation: MC) plays an important role in the development of common
cardiovascular diseases such as diabetes and hypertension. In the context of
cardiovascular disease development, causes and consequences of microvascular
dysfunction are relatively unknown. A plausible risk factor for microvascular
dysfunction is overweight, but the underlying pathways remain unclear.
Although, a contribution of microvascular dysfunction to the development of
diabetes and hypertension is suggested in previous studies, these experimental
studies are based on animal models and small human populations with extreme
phenotypes.
Hypotheses of this study:
1. Overweight leads to microvascular dysfunction via markers of low grade
inflammation (adipocytokines), endothelial dysfunction and disturbances in
lipid profile.
2. Microvascular dysfunction leads to an elevated blood pressure and a decrease
in insulin sensitivity.
3. Microvascular dysfunction is associated with early signs of atherosclerosis
The aforementioned relations will be tested in 200 apparently healthy subjects
divided in 2 groups based on glucose tolerance status in 2006 (i.e. normal or
impaired glucose tolerance). The structure and function of the MC will be
examined in the nailfold, using videomicroscopy. The data obtained regarding
structure and function of the MC can be related to body fatness, blood
pressure, large artery properties and serum sample parameters to unravel
underlying mechanisms. The proposed design is novel and allows to separate of
culprit mechanisms. Results of this study can confirm theories and may improve
prediction and prevention of cardiovascular diseases in the future.
Study objective
1. Do body fatness and/or body fat distribution show a linear association with
microvascular function in normal as well as IGT subjects?
2. Is the effect of body composition on the microvasculature mediated by altered
adipokine profile, low-grade inflammation and /or markers of endothelial
dysfunction?
3. Is microvascular dysfunction associated with reduced insulin sensitivity,
higher
blood pressure and/or dyslipidemia?
4. Is microvascular dysfunction associated with accelerated subclinical
atherosclerosis?
5. Is there a difference in microvascular function between normal and impaired
glucose tolerant subjects, matched for age, sex and BMI?
6. Are the associations studied under research questions 2-4 different between
NGT
and IGT subjects?
Study design
observational cohort study
Study burden and risks
Subjects are 43-68years and part of the original *New Hoorn* cohort as invited
in 2006. In the previous round of measurement participants were asked whether
they were willing to participate in and approved to be invited for follow-up
measures. Each subject is asked for a complete morning including an OGTT, 4
venapunctions, a complete body scan, carotis scan using echografie, capillary
microscopy video and anthropometry measurements. Completed with questionnaires
on lifestyle, perceived health and well being.
Boelaan 1081-1085
1081HV Amsterdam
NL
Boelaan 1081-1085
1081HV Amsterdam
NL
Listed location countries
Age
Inclusion criteria
participation in the last measure round of 2006 and written approval for contact in new measure rounds
Exclusion criteria
indication of diabetes (type I or II) and or diagnosed with malignant diseases last 12 months
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31152.029.10 |