The aim of the study is to observe whether microcirculatory perfusion follows the decrease in preload caused by hemodialysis in a population with an intact and a disturbed microcirculatory autoregulation.
ID
Source
Brief title
Condition
- Other condition
- Renal disorders (excl nephropathies)
Synonym
Health condition
intensive care patienten
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the sublingual microcirculatory perfusion.
Secondary outcome
not applicable
Background summary
The relation between systemic hemodynamic parameters and microcirculatory
perfusion is not clear. This is mainly important in patient populations with a
disturbed regulation of the fluidbalance, i.e. patients who require renal
replacement therapy. It is the question if it is possible to withdraw fluid
from the patient without compromising microcirculatory perfusion. We want to
investigate the effects on the microcirculatory perfusion in patients with a
adequate autoregulation of the microvasculture where the preload is decreased
in a short time interval. Additionally we want to study this relationship in a
patient population with a disturbed regulation of the microvasculature and
where preload is slowly decreased.
Study objective
The aim of the study is to observe whether microcirculatory perfusion follows
the decrease in preload caused by hemodialysis in a population with an intact
and a disturbed microcirculatory autoregulation.
Study design
The study will be carried out as a single center observational study on the
department of Intensive Care and the outpatient clinic of nephrology of the
Erasmus Medical Center.
Study burden and risks
The measurements will not involve risks for the subject. The measurement
methods are based on light with harmless wavelength. The measurement probes
will only slightly make contact with the sublingual area of the subject. The
time of dialysis will not be extended.
In the future patients could benefit from the results, by optimizing the
treatment based on individual parameters of microcirculatory perfusion
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
We will include two patientspopulations, firstly patients undergoing chronic intermittend renal replacement therapy in an outpatient clinic setting. Secondly we will include patients admitted to the intensive care unit who receive continuous veno-venous hemofiltration with ultrafiltration. Of both populations we will include 20 patients.
Inclusion criteria for patients receiving chronic intermittend renal replacement therapy:
- Age above 18 yrs
- Admitted for intermittend hemodialysis.;Inclusioncriteria for patients admitted to the intensive care unit who receive continuous veno-venous hemofiltration.
- Age above 18 yrs.
- Clinical indication for continuous veno-venous hemofiltration with ultrafiltration
Exclusion criteria
Exclusion criteria for patients receiving chronic intermittend renal replacement therapy:
- Circumstances making it impossible to perform sublingual measurements, like bleeding of the oral cavity.
- Patients who require no or only small amounts of ultrafiltration during hemodialysis. ;Exclusioncriteria for patients admitted to the intensive care unit who receive continuous veno-venous hemofiltration.
- Circumstances making it impossible to perform sublingual measurements, like bleeding of the oral cavity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31563.078.10 |