(1) This study will examine the effectiveness of CT and ACT in a randomized controlled trial conducted in a clinical setting. (2) Apart from being interested in differential effectiveness of the two approaches, we are also interested in whether…
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main dependent variables are
1) Self-reported distress on the Beck Depression Inventory (BDI; Beck et al.,
1961), and
2) Clinicial rated distress on the Hamilton Rating Scale for Depression (HRSD;
Hamilton, 1960).
Secondary outcome
Additionele afhankelijke variabelen:
- Quality of life: Eurohis Quality of Life Scale (Eurohis; Power, 2003).
1. Proces measures for ACT
1a. Decentering subschale of the Experiences Questionnaire (EQ; Fresco et al.,
2007)
1b.Acceptance and Action Questionnaire (AAQ-II) (Hayes et al., unpublished;
Dutch version: Jacobs, Kleen, de Groot, A-Tjak, 2008).
2. Proces measures for CT
2a. Dysfunctional Attitude Scale-revised (DAS-17; de Graaf et al., 2009)
2b. Implicit Attitude Test (IAT; Greenwald et al., 1998) adjusted for
depression.
Other (moderator/mediator) variabeles:
• Credibility/Expectancy Questionnaire (CEQ; Devilly & Borkovec, 2000.
• Working Alliance Inventory (WAI; Horvath & Greenberg, 1989) The Relationship
Scales Questionnaire (RSQ; Griffin, & Bartholomew, 1994).
• Cluster C personality traits will be assessed with the Personality Disorder
Beliefs Questionnaire (PBQ; Arntz et al., 2004).
Background summary
Of the psychological treatments for major depressive disorder (MDD), Cognitive
Therapy (CT) is the most systematically researched treatment. Recently, a
number of new *third-generation* behavioral and cognitive therapies have
emerged one of these being acceptance and commitment therapy. ACT uses
acceptance and mindfulness processes, and commitment and behavior change
processes, to produce greater psychological flexibility (Hayes, 2004). Although
there are fewer randomized controlled trials with ACT than with traditional
CBT, there is growing evidence that ACT is an effective approach in treating
different psychiatric disorders, including MDD. The popularity of ACT has
increased enormously in the last decade. Despite this, there is still lack of
well-designed randomized and controlled trials comparing the efficacy of ACT
with well-documented psychological treatments such as CT
Study objective
(1) This study will examine the effectiveness of CT and ACT in a randomized
controlled trial conducted in a clinical setting.
(2) Apart from being interested in differential effectiveness of the two
approaches, we are also interested in whether effects of each specific
treatment approach are mediated by its proposed theoretical mechanism, and
(3) whether personality characteristics and attachment style are related to the
effecs of these treatments
This study will examine the effectiveness of CT and ACT in a randomized
controlled trial conducted at PsyQ outpatient clinics in Zaandam and Purmerend.
More specifically, the hypothesis here is that CT is going to be more effective
in treating MDD than ACT. Apart from being interested in differential
effectiveness of the two approaches, we are also interested in whether effects
of each specific treatment approach are mediated by its proposed theoretical
mechanism.
Study design
The study design is a randomized clinical trial, in which patients are randomly
assigned to two treatments: (1) cognitive therapy and (2) Acceptance and
Commitment Therapy. Dependent variables will be assessed at pre-treatment, ,
post-treatment, 6 months post-treatment and 12 months post-treatment.
Intervention
The study concerns two psychological treatments:
• 16-20 sessions of cognitive therapy
• 16-20 sessions of Acceptance en Commitment Therapy
Study burden and risks
In both conditions, participants will receive bona fide treatments for major
depression. Content, intensity and duration of the treatment are comparable to
usual clinical care for this group within PsyQ Zaandam/Purmerend. In order to
study the effects of the treatment participants will be asked to fill in a
number of questionnaires and complete interview before treatment, at
mid-treatment, at post-treatment and at 6- and 12-months follow-up. The benefit
for individual participants concerns the fact that they receive a bona fide
treatment for their condition and that this treatment will be provided by
experienced therapists who will receive additional supervision for the cases
treated within the project. On a more general level, the study addresses a
highly relevant topic, which has to date been under-researched. The study has
the potential to greatly improve knowledge about the efficacy of psychological
treatments for major depression.
Roetersstraat 15
1018WB Amsterdam
NL
Roetersstraat 15
1018WB Amsterdam
NL
Listed location countries
Age
Inclusion criteria
1) Meeting DSM-IV criteria for MDD
2) between the ages of 18 and 65-years-old
3) having sufficient fluency in Dutch to complete treatment and research protocol
4) Participants using prescribed anti-depressant medication are required to be on a stable dose for at least 2 weeks before the beginning of treatment and remain on this dose throughout the treatment.
Exclusion criteria
1) DSM-IV criteria for bipolar disorder (past and/or present)
2) psychotic disorders
3) substance dependence disorders (current or within the past 6 months), or
4) organic brain syndrome.
5) borderline or antisocial personality disorder
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31937.018.10 |