To investigate whether the rate of gastric emptying differs between a low viscosity milk product and an iso-caloric high viscosity milk product.
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study outcome is gastric emptying (and the variation in that
measurement). Gastric emptying will be measured with a non-invasive breath
test. The subject will come in fasting state to the research centre and ingest
the test product which is labelled with 13C. The test foods consist of 2
chocolate flavoured milk products, differing in viscosity. Breath samples will
be collected before consumption of the food and at 15 minute intervals during 3
hours. Breath samples will be analyzed on concentration of 13C. 13C recovery
(T1/2 and Tlag) will be used as a measure for gastric emptying.
Secondary outcome
Appetite and wellbeing ratings will be measured during the test by means of
Visual Analogue Scales.
Background summary
We have shown previously that low viscosity products seem to elicit weak
satiating responses compared to high viscosity products. About 30% more low
viscosity milk products are consumed to satiation compared to iso-caloric high
viscosity products. As high viscous products are also known to be released much
slower from the stomach, it might be that the difference in satiating capacity
can be explained by differences in gastric emptying.
Study objective
To investigate whether the rate of gastric emptying differs between a low
viscosity milk product and an iso-caloric high viscosity milk product.
Study design
Cross-over experiment with 2 gastric emptying measurements per subject. In one
of the conditions a fixed amount of 500g of the low viscosity product will be
consumed, in the other condition a fixed amount of 500g of the high viscosity
product. Food products are randomized and balanced.
Intervention
Cross-over experiment with 2 gastric emptying measurements per subject. In one
of the conditions a fixed amount of 500g of the low viscosity product will be
consumed, in the other condition a fixed amount of 500g of the high viscosity
product. Food products are randomized and balanced.
Study burden and risks
Subjects will have to come 2 times to the research centre to undergo the breath
test (3-4 hours). Prior to participation subjects will have a screening visit
of ca. 15 minutes (inclusion questionnaire; measurement of weight and height;
explanation of the procedure).
The study is non-therapeutic to the participant. The risk associated with
participation is negligible. Compared to other studies, the burden can be
considered as low. No invasive measurements are present.
Postbus 8129
6703 HD Wageningen
Nederland
Postbus 8129
6703 HD Wageningen
Nederland
Listed location countries
Age
Inclusion criteria
*Apparently healthy, self reported
*Young adult males: 18-30 year
*Normal weight: BMI 18.5-25 kg/m2
*Used to eating breakfast (> 5 times per week)
*
Exclusion criteria
*Loss of appetite
*Weight change of >5kg during the last 2 months
*Being on a weight loss diet
*On a prescribed diet that interferes with the study foods
*Bowel or stomach disorder
*Diabetes or thyroid disorder
*Food intolerance or allergy for foods that are provided during the study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31352.081.10 |