1) What is the long-term course of tics and comorbid OCD, ADHD and Quality of life in patients with GTS? 2) What are determinants of favourable versus unfavourable course?
ID
Source
Brief title
Condition
- Other condition
- Neurological disorders congenital
- Anxiety disorders and symptoms
Synonym
Health condition
bewegingsstoornissen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome variables will be (change in) tic diagnosis and tic severity
using the Yale Global tic severity scale (YGTSS).
Secondary outcome
Secondary outcome variables are: (change in) OCD diagnosis and OC symptom
severity (measured with the YBOCS), (change in) ADHD diagnosis and severity
(measured with the CAARS), and (change in) Quality of Life measured with the
QOL. Information obtained through the partners will be used in the analyses to
establish pschosoial functionning in the patients.
The following variables are used to enter in the models as predictors of
outcome: baseline tics/ tic severity, baseline OC symptom severity, baseline
severity of ADHD, age at onset, illness duration, sex, family history, number
and severity of life events, and psychosocial status at baseline.
Neuropsychological parameters that are used in association with tic severity,
and severity of comorbid OCD/ ADHD are: Stroop color-word test and Stroop
interference control (cognitive inhibition), Go-no-Go task (motor inhibition),
ID/ED set shifting task.
Background summary
On the course of Gilles de la Tourettes disorder (GTS) and its comorbidities
(most importantly OCD and ADHD), only small retrospecitive studies (including
between 20-60 patients, in children and adolescents) have been published to
date, that require replication and extension. Naturalistic studies on course in
adults with GTS have not yet been carried out. Thus, little is known on
specific environmental factors associated with long-term outcome of tics,
comorbidities and quality of life in GTS patients.
The aim of this project is therefore to answr clinically important questions
such as: What are specific provocative factors, what are the protective factors
involved in long term persitence or remission of tics (and comorbid OCD and
ADHD)? What is the role of gender in tic development? To what extent are tics
and comorbid OCD and ADHD more persistent in adults than in children and
adolescents? What is the influence treatment on the persistence or reduction
of symptoms in the longer term? To what extent are socio-economic factors, life
events, and comorbid disorders/traits predictors of course?
The current study will be the first larger-scale study that investigates course
and predictors of outcome in GTS using dfferent age groups as a starting
point.
Study objective
1) What is the long-term course of tics and comorbid OCD, ADHD and Quality of
life in patients with GTS?
2) What are determinants of favourable versus unfavourable course?
Study design
This project encompasses a naturalistic follw-up study that will be carried out
at the department of clinical and health psychology of Utrecht university. All
patients with GTS who have visited the anxiety outpatient clinic of GGZ
Buitenamstel (Amsterdam) between 2001 and 2008, either to receive treatment or
counseling, or -through the GTS patient society- and who has participated in a
genetic study, will be recontacted and re-invited for the follow-up study.
After written informed consent has been given, a research assistant will send
self-report questionnaires to fill out.
Further, the patient is interviewed, either at the department of clinical and
health psychology or in the home situation.
The questionnaires and interview include: assessment of tics and comorbidity
according to DSM-IV criteria, quantitiative measurements of symptom severity);
assessment of risk and protective factors of course (a.o. life-events,
demographic factors, perinatal adversity). In addition, from the partners of
patients (when available) information will be requested on the patients'
symptoms and psychosocial functioning.
Further, neuropsychological tests are added to the follow-up measurement,
targeted at asessing the ability of (motor and cognitive) inhibition and
switching.
About 80% of the follow-up measurements will be identical to the baseline
measurements. New measurements added to the follow-up include: questionnaires
on impulsivity and life events. Further neuropsychological testing is added.
For an overview of all tests, see appendix 1 & 2 of the protocol.
All data are entered and stored in a database after datacleaning. Subseuqntly,
data are analysed using growth curve analyses with model fitting procedures in
mplus.
Study burden and risks
The risks associated with participation are minimal. The time span and
emotional feelings evoked by the questionnaires might cause some burden for the
patient.
Heidelberglaan 1
3584 CS utrecht
NL
Heidelberglaan 1
3584 CS utrecht
NL
Listed location countries
Age
Inclusion criteria
Persons with GTS and their partners.
Exclusion criteria
Persons on whom baseline measurements are incomplete or un available.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31720.041.10 |