To investigate the incidence of CIN in three hospitals where patients are treatedaccording to the current guidelines, to identify the prediction risk factors and toobtain blood and urine samples that will allow future identification and evaluation…
ID
Source
Brief title
Condition
- Nephropathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incidence of CIN in patients treated according to the current guidelines, risk
factors associated with CIN, accuracy of selected biomarkers
Secondary outcome
none
Background summary
Contrast media are frequently used in diagnostic and therapeutic procedures.
Acute renal failure is still a regular and severe complication seen after
administration of intravascular iodinated contrast media.
This contrast-induced nephropathy (CIN) (defined as a rise of serum creatinine
> 25% within 48 to 72 hours after administration,) is associated with marked
morbidity and mortality.
It is therefore important to recognize the patients at risk and to take
appropriate preventive measures.
Study objective
To investigate the incidence of CIN in three hospitals where patients are
treated
according to the current guidelines, to identify the prediction risk factors
and to
obtain blood and urine samples that will allow future identification and
evaluation of
biomarkers for the early detection of CIN.
Study design
multi-centre prospective cohort study
Study burden and risks
There are no major associated risks resulting from filling in the questionnaire
and by taking two additional blood sample and two additional urine samples per
person, compared to standard procedure.
Hatertseweg 299
6533 AK Nijmegen
NL
Hatertseweg 299
6533 AK Nijmegen
NL
Listed location countries
Age
Inclusion criteria
Adult patients (>18 yrs) with an estimated GFR<60ml/min, who are scheduled for an elective procedure that involves the intravascular administration of iodinated contrast media
Exclusion criteria
Age <18, the inability to provide written informed consent, GFR >60ml/min
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL31607.091.10 |