Can we identify a gene expression profile for late radiation toxicity?
ID
Source
Brief title
Condition
- Reproductive and genitourinary neoplasms gender unspecified NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- gene expression profile in lymphocytes
- toxicity questionnaire
Secondary outcome
-
Background summary
Late radiation toxicity is the major dose limiting factor of radiotherapy. The
risk of radiation toxicity depends of radiation dose and -volume, but probably
also of a genetic predisposotion.
Study objective
Can we identify a gene expression profile for late radiation toxicity?
Study design
retrospective case-control study.
Study burden and risks
vena punction (minor inconvenience) and a questionnaire
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
adult males at leats 2 years after curative radiotherapy for prostate cancer
no evidence of prostate cancer
two groups are selected:
with severe toxicity (SOMA grade 3-4), or
with no or mild toxicity (grade 0-1)
Exclusion criteria
- patients who had prostatectomy or brachytherapy
- patients with severe mental or somatic disorders
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL30056.018.09 |