The main objective of this specific study is to examine to what extend differences in cognitive functioning between people are due to complex interactions between genes and environment.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Individuele verschillen in normaal cognitief functioneren m.b.t. attentie en geheugen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cognitive abilities will be measured by subtests of an intelligence scale, some
working memory tests and some language tests.
Environmental factors will be measured by an online questionnaire, that
includes questions on factors which are possible correlated with IQ,
home-environment in youth, hobby*s and interests, but also work and education
and work and education from parents, friends and spouses, personality factors
and performance motivation.
Dna will be collected using saliva, which requires subjects to spit in a small
tube during 1-3 minutes, only from adults
Secondary outcome
none
Background summary
This project is part of a large project entitled *Finding Genes through the
Environment*.
In earlier studies cognitive data from twins and siblings have been collected.
To be able to measure more complex processes as *cultural transmission* and
*assortative mating* cognitive and environmental data will be collected from
multiple generations (parents, children and spouses of twins). We will use a
general variance components approach in which variation in a trait is
decomposed into genetic variation and environmental variation, using structural
equation modeling and family based designs (Neale and Cardon, 1992). The
complex interplay of genes and environment in the context of cognitive
abilities will be investigated by analyzing genotypes and cognitive ability and
environmental influences in genetically informative designs.
Study objective
The main objective of this specific study is to examine to what extend
differences in cognitive functioning between people are due to complex
interactions between genes and environment.
Study design
Test research, questionnaires and statistical analyses.
Study burden and risks
We don*t expect any risks for the subjects in this study. The burden will be
kept as small as possible. Questionnaires can be filled out online. It takes
about 60 minutes to fill in the questionnaire. All subjects will be asked to
make several neuropsychological tests. This will take about 90 minutes,
including a 15-minutes break. The test battery consists of some subtests of an
intelligence scale, some working memory tests and an attention task.
To be able to draw conclusions about gene functioning in cognition, genetic
material (DNA) will be collected, using saliva. This is easily collected by
spitting in a small tube during 1-3 minutes.
de Boelelaan 1085
1081 HV Amsterdam
NL
de Boelelaan 1085
1081 HV Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Partners from the general population, aged above 18
This amendment: healthy children aged 8-15 (adjusted protocol)
Exclusion criteria
Illiterate, worse knowledge of the Dutch language, hard of hearing, poor eyesight, neurological diseases.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13178.029.06 |