The primary objective of this first study is to explore the short-range stability of cortico-cortical networks in healthy volunteers by measuring resting state EEG.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
onderzoek bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cortico-cortical networks will be reconstructed by computing the level of
statistical dependency between the electrode signals across different frequency
bandwidths (1-30Hz), by means of computing the level of coherence between the
time-series of the different electrodes. From the resulting individual
cortico-cortical networks, graph metrics that describe the topology of the
network will be computed, with the mean focus on the level of degree -number of
connections in the network-, local efficiency -expressing the level of local
clustering of nodes- and global efficiency -computed as the inverse of the
minimal number of steps to travel between any two nodes, expressing how
efficient information can be transported between different parts of the
network. Next, network stability will be assessed by determining the
test-retest reliability of these metrics across the different time-points for
the different frequency bandwidths across the group of subjects.
Secondary outcome
not applicable
Background summary
The human brain consists of complex networks. Despite the fact that different
brain regions have their on functional specialization, together they form
networks that exhange information and in order for the brain to function
properly stability within these networks is essential. However, this has never
been studied in a systematic way. The aim of this study is to examine the
stability of these networks.
Study objective
The primary objective of this first study is to explore the short-range
stability of cortico-cortical networks in healthy volunteers by measuring
resting state EEG.
Study design
Participants will be prepared for the EEG recording (20 minutes) and electric
brain activity will be recorded from 64 positions for one hour (i.e., 6 blocks
of 8 minutes). Participants will be seated in a comfortable reclining chair and
instructed to relax. A short pause of a few minutes will be given after every 8
minutes of recording. During the recording eight minutes of 1 minute eyes-open
and 1 minute eyes closed will be recorded. Prior to the EEG session
participants will be asked to refrain from taking psychotropic substances,
including coffee, tea and chocolate at least 2 hours prior to the EEG
recording. Graph analyses will be applied to the EEG data to extract the
networks and stability of these networks will be determined.
Study burden and risks
Burden: Time investment of 90 minutes (traveling time not included) and wearing
an electrode cap.
Risks: There are no risks involved with EEG scalp recordings.
Heidelberglaan 2
3584CS Utrecht
NL
Heidelberglaan 2
3584CS Utrecht
NL
Listed location countries
Age
Inclusion criteria
Males: Healthy, right-handed, non-smoking volunteers, aged between 18-35 years ;
Females: Healthy, right-handed, non-smoking, aged between 18-35 years, using contraceptives
Exclusion criteria
Metal in cranium, use of psychotropic drugs, including cannabis, XTC, amphetamines and cocaine, epilepsy or family history of epilepsy, history of closed-head injury, history of head surgery, history of neurological or psychiatric disorders, medication use (i.e., benzodiazepines, antidepressants and neuroleptica), brain infarction, pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38783.041.11 |