To investigate whether bone mineral density is lower in apheresis donors than in blood donors.
ID
Source
Brief title
Condition
- Bone disorders (excl congenital and fractures)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is bone mineral density, measured by dual X-ray
absorptiometry
Secondary outcome
The bone turnover markers C-telopeptide (CTX) and N-terminal propeptide of
type 1 collagen (P1NP).
Background summary
It is known that there are short term changes of serum calcium during apheresis
procedures. Less is known about the consequences of this during long term
follow-up, such as decrease of the bone mineral density. When this occurs, it
could be advisable to supplement calcium during the apheresis procedure.
Study objective
To investigate whether bone mineral density is lower in apheresis donors than
in blood donors.
Study design
case control study
Study burden and risks
Discomfort is possible during vena punction. Radiation of the DXA-scan is low,
about 10-15% of that of a thorax X-ray.
De Boelelaan 1117
1081 HV Amsterdam
NL
De Boelelaan 1117
1081 HV Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Women between 55 en 70 years old, who underwent apheresis donation at least a hundred times.
Control subjects: women between 55 en 70 years old who are blood donor for at least 15 years.
Exclusion criteria
- smoking
- use of certain medication during inclusion period, such as corticosteroids and bisphosphonates.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37527.029.11 |