The main objective is to study pregnancy rates after using metabolomic profiling added to the selection of viable embryos by morphology, compared to using only morphology.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
embryologie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Live birth rate
Secondary outcome
Ongoing pregnancy rate
Background summary
The high multiple pregnancy rate caused by IVF treatment leads to a higher
incidence of medical, perinatal and neonatal complications and hence to higher
health care costs. Single Embryo Transfer (SET) is an effective way to minimize
risks of multiple pregnancies. Only one embryo is transferred, so the selection
of the embryo with an optimum implantation potential very important. Currently,
embryo selection is mainly based on morphological criteria using light
microscope analysis. Because of its limited predictive value for ongoing
pregnancy, new selection tools are being sought-after. Previous study showed
that non-invasive metabolomic profiling seem to provide a strong addition to
the selection of viable embryos and may serve as a useful methodology for
rapid, non-invasive embryo selection. We hypothesize that pregnancy rates may
improve when a more sensitive and specific selection tool like metabolomic
profiling of biomarkers of oxidative metabolism by Near Infrared (NIR)
Spectroscopy is used.
Study objective
The main objective is to study pregnancy rates after using metabolomic
profiling added to the selection of viable embryos by morphology, compared to
using only morphology.
Study design
Prospective, randomised, controlled, double blind trial.
Intervention
it is possible to select a different embryo compared to the conventional
selection.
Study burden and risks
none: the patients will get a standard IVF or ICSI treatment, only the fluid in
which the embryo was grown will be analised.
Amstelveenseweg 601
1081 JC Amsterdam
NL
Amstelveenseweg 601
1081 JC Amsterdam
NL
Listed location countries
Age
Inclusion criteria
the transfer of one embryo (single embryo transfer-SET)
Exclusion criteria
patients where a double embryo transfer (DET) is performed
patients with less than 2 embryos of similar morphology
patients are allowed to participate in the study for one IVF/ICSI cycle
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17593.000.07 |