The aim of this study is to investigate how often thymic hyperplasia is present in Graves' disease. Moreover we will investigate if thymic hyperplasia in Graves' disease is caused by stimulation of T cell development in the thymus.
ID
Source
Brief title
Condition
- Other condition
- Thyroid gland disorders
Synonym
Health condition
thymus hyperplasie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Presence of thymic hyperplasia.
Secondary outcome
Increase of naive T cells in the blood.
Increase in TRECs in the blood.
Background summary
Graves' disease is associated with thymic hyperplasia. Since it is known that
the TSH receptor is also present in the thymus, stimulating antibodies against
the TSH receptor could play a role in thymic hyperplasia. Moreover high
concentrations of TSH are able to stimulate T cell development in vitro.
Study objective
The aim of this study is to investigate how often thymic hyperplasia is present
in Graves' disease. Moreover we will investigate if thymic hyperplasia in
Graves' disease is caused by stimulation of T cell development in the thymus.
Study design
30 patients with Graves' disease who will be treated with radioactive iodine
therapy will be recruited on the nuclear medicine department. After the
radioactive iodine scan according to the regular treatment, an extra scan will
be made from the thymus. Moreover blood samples of these patients will be
taken.
Study burden and risks
An extra scan will be made, which takes 10 minutes, there is no extra exposure
to radiation since patients already recieved the radioactive iodine for their
normal treatment. Moreover blood samples will be taken.
Participation to this study does not involve extra risks.
Dr. Molewaterplein 50-60
3015 GE Rotterdam
Nederland
Dr. Molewaterplein 50-60
3015 GE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Graves' disease
radioactive iodine treatment
Exclusion criteria
use of corticosteroids
older than 50 years of age
psychiatric diseases
pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL22657.078.08 |
| OMON | NL-OMON25605 |