To asses the agreement of KNN volumetry on 1,5 and 3 Tesla MRI.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The agreement of KNN volumetry applied on 1,5 and 3 Tesla MRI of the same
subject.
Secondary outcome
n.a.
Background summary
K-Nearest Neighbour (KNN) volumetry is a highly accurate method for segmenting
brain MRI into the compartments gray matter, white matter, cerebrospinal fluid
and white matter hyperintensities and measuring the volumes of these
compartments. KNN volumetry has been successfully applied to 1,5 Tesla brain
MRI in several studies at the UMCU that addressed brain volumes in the context
of vascular brain disease and cognitive decline.
At present, research projects increasingly rely on 3 Tesla scans. The main
reason for switching to 3 Tesla MRI is the superior signal to noise ratio which
has advantages for methods other than brain volumetry. Although field strength
should not have a major impact on KNN volumetry, it has not been established
yet if volumetric results are similar at different field strengths.
In this study we will asses the level of agreement between KNN volumetry on 1,5
and 3 Tesla MRI. Agreement between KNN volumetry on 1,5 and 3 Tesla MRI would
allow us to:
- Link volumetric data from 1,5 Tesla projects to 3 Tesla projects.
- Use volumetric data from existing large 1,5 Tesla cohort studies (such as the
SMART-Medea study, >1500 MRI scans) as reference data for current and future 3
Tesla projects.
- Perform multicenter studies using both 1,5 and 3 Tesla MRI scans.
Study objective
To asses the agreement of KNN volumetry on 1,5 and 3 Tesla MRI.
Study design
Cross sectional observational study.
Study burden and risks
The burden associated with participation is that subject will receive two brain
MRI scans on the same day. No contrast agent will be administered. Total scan
time will be approximately one hour. There are no known risks associated with
brain MRI scanning.
Heidelberglaan 100
3584CX
NL
Heidelberglaan 100
3584CX
NL
Listed location countries
Age
Inclusion criteria
We will select our subjects from a cohort of patients with Chronic Idiopatic Axonal Perpiheral neuropathy (CIAP).
Inclusion criteria:
Age 50-80 years, a history of cardiovascular disease, 1 or more of the following cardiovascular risk factors: hypertension, diabetes mellitus, BMI > 29, > 10 packyears.
Exclusion criteria
Not living independently. History of brain disease. Contra-indication for MRI: AICD/ICD (automatic heartdefibrillator), Aneurysm clips in the brain placed before 1986 (AZU) or 1990 (Tilburg), Recent endoscopically placed clips in the intestinal system, Breast (mamma) expander with magnets, Cochleair implants, Metal corpus alienum in the eye, Electrical wires (pacemaker wires, ECG wires), Implanted insulin pump, Heart valve prothesis Braunwald - Cutter, Neurostimulator and Vagal Nerve stimulator, Pacemaker, Piston from 1985-1987, Provox ActiValve voisceprothesis, Zenith AAA stent made by Cook, Swan-Ganz catheter, Dental braces, Hydrocefalus pumps, Markers for proton radiation, Piercings, Protheses of 30cm.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37915.041.11 |