The aim of this study is to determine the levels of hemostasis factors after an uncomplicated pregnancy.
ID
Source
Brief title
Condition
- Coagulopathies and bleeding diatheses (excl thrombocytopenic)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Concentration of hemostasis factors (Activated Protein C, protein C, protein S,
APTT, trombotest, antitrombin, factor V Leiden, protrombine, lupus
anticoagulans-test, anti-cardiolipine antibodies, von Willebrand factor)
Secondary outcome
n.a.
Background summary
In blood samples, collected 3 months after a complicated pregnancy, the levels
of hemostasis factors are often abnormal and associated with thrombophilia.
With repeated measures, at least 1 month later, the levels are often
normalized. It is known that hemostasis factors change during pregnancy. In
this project we want to study whether the abnormal levels we measure 3 months
postpartum are realy abnormal or whether the observed abnormalities are the
consequence of the pregnancy. If this is the case, the reference values for
this group of women needs to be changed.
Study objective
The aim of this study is to determine the levels of hemostasis factors after an
uncomplicated pregnancy.
Study design
2 x sampling of 10 ml blood, 3 months and 6-9 months after delivery.
Study burden and risks
minimal burden (2x venapunction)
Postbus 2040
3000 CA Rotterdam
NL
Postbus 2040
3000 CA Rotterdam
NL
Listed location countries
Age
Inclusion criteria
uncomplicated pregnancy, age > 18 years
Exclusion criteria
complicated pregnancy (preeclampsia, HELLP-syndrome), history of repeated miscariages, growth retardation, hemostasis abnormalities
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL24511.078.08 |