In this study we test the hypothesis that a divisional calculation of heat loss, and incorporation of skin temperature of the extremities during mild cold exposure will indicate an age effect on heat loss between young and elderly males and females…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
aandoeningen bij thermoregulatie ten gevolge van voortgang in leeftijd
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Heat storage, Rate of change of heat storage
Secondary outcome
-
Background summary
In general elderly are predisposed to risk of both hypothermia and
hyperthermia, even at mild cold or heat exposure. Studies aimed at age related
changes in mechanisms of thermoregulation to explain the increased risk of
elderly failed to observe differences in heat loss between young and elderly.
This might be caused by a lumped approach of calculation of heat loss through
mean skin temperature without incorporation of temperatures of the extremities.
Furthermore it is known that males and females differ in thermoregulation.
Therefore, a second objective of this study is to explore gender effects in
heat loss and heat storage.
Study objective
In this study we test the hypothesis that a divisional calculation of heat
loss, and incorporation of skin temperature of the extremities during mild cold
exposure will indicate an age effect on heat loss between young and elderly
males and females. An additional purpose is to test whether hysteresis effects
are measurable between cooling and warming subjects
Study design
Cross-over design covering both exposure to a mild cold and mild warm
environment. Subjects will be studied on two separate occasions, where they are
subjected to either a cold to warm or warm to cold temperature transition
Study burden and risks
Subjects are required to visit the laboratory three times. The first visit is
to select and match subjects based on body composition characteristics
(duration 1 hour). The second and third visit concerns the actual experiment
(duration 4 hours). Further than possible discomfort due to exposure to a mild
cold and mild warm environment, no significant burden or risk for the subjects
is expected.The capsule for core temperature measurement is designed for human
use only. The capsule is easily swallowed and is not sensed during the rest of
its tract through the body. The blood collection can cause a contusion.
Universiteits Singel 50
6229 ER Maastricht
NL
Universiteits Singel 50
6229 ER Maastricht
NL
Listed location countries
Age
Inclusion criteria
• Caucasian healthy male or female
• Age between 18 to 28 years or age between 68 to 78 years
• 20 kg/m2 < BMI < 25 kg/m2
• 15% < Fat percentage < 30%
• 1.8 m2 < Dubois skin area < 2.0 m2
• 80mmHg < Mean arterial pressure < 90mmHg (rest, supine position)
for females- using combination anti-conseption or using no anti-conception
Exclusion criteria
• History of cardiovascular disease
• Carrier of electrically-sensitive implanted devices
• Deviant core temperature at day of experiment
• General feeling of illness at day of experiment
• For females-the use of only estrogen or progesteron
• Smoking
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL29167.068.09 |