to investigate if small nerve fibres are affected in patients with ICU-AW
ID
Source
Brief title
Condition
- Ancillary infectious topics
- Peripheral neuropathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- the difference in intra-epidermal nerve fibre density measured using
bright field immunohistochemistry between patients with ICU-AW and normative
values matched for age and gender known in the literature
Secondary outcome
- correlation between muscle strength and IENF density
- correlation between clinical markers (e.g sensory disturbances) for small
nerve fibre function and IENF density
- correlation between temperature discrimination threshold and IENF density
- deposition of various inflammatory markers using immunohistochemistry
- density of post ganglionic sympathetic fibres
Background summary
Intensive Care Unit-acquired weakness, a frequently occurring complication of
critical illness, can be caused by muscle dysfunction (critical illness
myopathy; CIM), nerve dysfunction (critical illness polyneuropathy; CIP) or a
combination (critical illness neuromyopathy; CINM). Differentiation between
these disorders is difficult with current diagnostic methods. Skin biopsy is a
valuable tool for diagnosis and understanding of various neuromuscular
disorders. Its use has not been investigated in Intensive Care Unit-acquired
weakness because it is not known if small nerve fibres are affected.
Study objective
to investigate if small nerve fibres are affected in patients with ICU-AW
Study design
observational cohort study
Study burden and risks
patients with diagnosed with ICU-AW will be investigated once after day 25
after ICU admission using a skin biopsy and several clinical markers of small
nerve fibre function and general markers of neurologic function. Skin biopsy is
safe method when the proper techniques are employed. If small nerve fibre
damage is found, subsequent studies can investigate its usability to improve
diagnostics and understanding of ICU-AW.
Meibergdreef 9
Postbus 22700, 1100 DE Amsterdam
NL
Meibergdreef 9
Postbus 22700, 1100 DE Amsterdam
NL
Listed location countries
Age
Inclusion criteria
diagnosed with Intensive Care Unit - acquired weakness
available in het AMC for investigation 25 days after ICU admission
Exclusion criteria
risk factor for small fibre neuropathy
bleeding disorder
delayed wound healing
leukopenia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL38545.018.11 |