The aim of this study is to determine the sensitivity of ultrasound in diagnosing the presence of an OCD in the ankle joint at locations that can be visualized compared to CT.
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- presence or absence of a OCD on ultrasound
- presence or absence of a OCD on CT
Secondary outcome
- size of the lesion
- location of the lesion
- Berndt and Harty classification of the lesion
Background summary
Osteochondral defects usually occur after a traumatic event. Diagnosis takes
place with MRI- or CT-scan, as radiographs are unsuitable. Bone marrow
stimulation is the first-line treatment option where loose cartilage pieces are
removed and holes are drilled in the underlying bone which stimulates an
intrinsic healing process. Although the treatment is quite successful, the
results are fair to poor for about 10% of the patients. This can only be
partially explained by factors such as defect size. Additionally, little is
known about the true nature of the healing process. So, there is a need for in
vivo monitoring to optimize this treatment. CT is unsuitable due to its
ionizing radiation, and MRI is expensive and time consuming. Recently,
ultrasound proposed as a means to visualize cartilage surfaces and detect small
bony lesions. Although ultrasound can not reach all locations in a joint, it is
noninvasive, dynamic and cheap to apply.
Study objective
The aim of this study is to determine the sensitivity of ultrasound in
diagnosing the presence of an OCD in the ankle joint at locations that can be
visualized compared to CT.
Study design
In total, 20 patients with a confirmed OCD on CT in ankle joint are recruited.
Patients should be older than 18 years and competent. An independent physician
will perform an independent diagnosis with ultrasound. The ultrasound images
are recorded simultaneously with the tracking data of the position of the
probe. This allows mapping of the ultrasound to CT-data. A second independent
physician performs diagnosis based on the CT-data as part of the routine
protocol.
Study burden and risks
No interventions will take place. Besides filling out the informed consent and
a questionnaire, diagnosis with ultrasound is performed twice. There are no
risks for the patients. Based on the results, it is decided if ultrasound is a
good research tool for longitudinal in vivo monitoring of the healing process
of osteochondral defects. This can possibly lead to improved surgical treatment
and early detection of osteochondral defects.
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
- Patients should have an age 18 years or older
- Patients should be able to read the patient information
- Patients who have received a routine CT-scan of the ankle which shows an OCD of the ankle and were either treated conservatively or are on the waiting list to receive any type of surgical treatment for the confirmed OCD.
Exclusion criteria
- Patients with suspected multiple pathologies in the ankle joint
- Patients that did not receive a CT-scan
- Patients with age lower than 18 years
- Patients who are pregnant
- Patients who have not signed the informed consent form
- Patients with a previous surgical history of OCD in the ankle.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37854.018.11 |