The objective of this research, which is a small part of the BioMod UE_PTL project, is to determine the relation between the electrical activity and the mechanical contraction of the uterus. This can greatly contribute to comprehension of the EHG.
ID
Source
Brief title
Condition
- Pregnancy, labour, delivery and postpartum conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The first main endpoint is a protocol for imaging the myometrium during
contraction using ultrasound. The results should be of a sufficient quality to
permit image analysis by segmentation or cross correlation algorithms. The
next step is to obtain, from this segmented myometrium, a parameter which is a
good measure for the contractility of the uterus. The final endpoint is to
obtain an estimate of the relation between the electrical activity and the
mechanical contraction.
Secondary outcome
nvt
Background summary
Preterm labor and subsequent preterm birth are the most common pregnancy
complications. One of the keys to treat preterm labor is the early detection of
labor. This can be done by analyses of some parameters which are derived by the
electrohysterogram (EHG). However, the EHG measures the electrical activity and
gives no direct information about the resulting mechanical activity. Ultrasound
imaging can be used to image the mechanical aspects of the contraction of the
uterus and can thus help to interpret the EHG. Furthermore, a multiscale model
will be developed by others to describe the relation between the biological
phenomenon involved in uterine cell contractility and the obtained EHG signals,
which is yet unknown. The ultimate goal of this total BioMod UE_PTL project is
to provide the knowledge to create a clinical tool that can detect the presence
of pathological uterine contractility leading to preterm labor.
Study objective
The objective of this research, which is a small part of the BioMod UE_PTL
project, is to determine the relation between the electrical activity and the
mechanical contraction of the uterus. This can greatly contribute to
comprehension of the EHG.
Study design
Ultrasound recording on pregnant women. Simultaneous EHG recordings will be
performed to determine the electrical activity.
Study burden and risks
There are no conceivable risks involved for the patients. Non-invase tests will
be used, which will not affect the outcome for the patient.
Postbus 7777
5500 MB Veldhoven
NL
Postbus 7777
5500 MB Veldhoven
NL
Listed location countries
Age
Inclusion criteria
Singleton pregnancy, >=30 weeks gestational age
Exclusion criteria
Multiple pregnancy, age < 18 year
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL37213.015.11 |