The aim of this study is to compare the colonization capacity of methicillin-susceptible S. aureus (MSSA) from animal and human origin in a human nose inoculation experiment.
ID
Source
Brief title
Condition
- Bacterial infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The survival rate of the animal S. aureus strain in the human nose after the
follow-up period of 14 weeks.
Secondary outcome
not applicable
Background summary
In The Netherlands an increase in MRSA cases is observed in particular in rural
areas and concerns in most cases people who have been in contact with farm
animals or livestock. There are speculations that these animal associated
bacteria are poorly equipped to colonize humans and that they are of reduced
risk to transmit to other people. Do we therefore need to imply the time
consuming and expensive Search and Destroy policy on every MRSA case that
enters a hospital or are less drastic measures indicated?
Study objective
The aim of this study is to compare the colonization capacity of
methicillin-susceptible S. aureus (MSSA) from animal and human origin in a
human nose inoculation experiment.
Study design
We propose an intervention-based prospective experimental follow-up study. We
intend to include 20 healthy volunteers.
Intervention
inoculation in the nose with a mixture of an animal and human S. aureus strain
Study burden and risks
Volunteers will have no benefits by participation in this study. The results
obtained by this study might have a profound impact on the application of the
Search and Destroy policy, as these data could form the basis for criteria to
formulate a second less drastic (and less expensive) Search and Destroy
protocol.
Noorderhavenkade 165 A 2
3039 RS Rotterdam
NL
Noorderhavenkade 165 A 2
3039 RS Rotterdam
NL
Listed location countries
Age
Inclusion criteria
healthy individuals
Exclusion criteria
Diabetes mellitus, renal insufficiency, COPD, heart diseases, immunocompromised status (HIV, AIDS) or use of immunosuppressants, use of antibiotics, allergy for mupirocin of penicillin, skin diseases such as eczema.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35960.078.11 |