To study the effect (signal, accuracy) of varying CO2 blood gas levels as well as different capillary blood temperatures on the SpO2 sensor signal. From the data obtained in this study the feasibility to derive the arterial CO2 value at 0.3 kPa…
ID
Source
Brief title
Condition
- Respiratory tract therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The venous and arterial bloodgas values
Secondary outcome
nvt
Background summary
Study the feasibility of extending the SpO2 sensor functionality towards
arterial CO2 monitoring. SpO2 forms a widely accepted technology and can be
used at home by non-professionals. By modulating for example, the oxygen
concentration supplied to the patient or the capillary blood temperature under
the SpO2 probe the partial carbon dioxide pressure can in principle be derived
from the oxygen saturation signal. This is based on the Bohr-Haldane effect:
the Oxygen-Hemoglobin Dissociation Curve (OHDC) - the relation between the
partial oxygen pressure and the oxygenation - is a function of the pH and thus
of the PaCO2.
Study objective
To study the effect (signal, accuracy) of varying CO2 blood gas levels as well
as different capillary blood temperatures on the SpO2 sensor signal. From the
data obtained in this study the feasibility to derive the arterial CO2 value at
0.3 kPa accuracy from a modulation of either the capillary blood temperature or
the inspired gas mixture (under well-controlled conditions) can be
determined.
Study design
prospective, open, convenience sample of patients who have an operative
indication voor non-cardiac vascular disease.
Intervention
A "formal"apnoe test, such is common practice during determination of brain
death (i.e. 4-6 L/min of oxygen in the endotracheal tube, while the PaCO2 is
allowed to rise) will be performed twice. veneus and aretrial blood gassen wil
be used to monitor and as data. Additional bloodgasses will be performed during
the reopenning of the vasculature (pH changes dur to revascularisation) and
during the final phase of anesthesia (some acculmutaion of CO2 as spontanneous
ventilation returns.
Study burden and risks
The additional risks due to an apnea test are negligible. The limits between
which PaCO2 and SpO2 will be varied conform to good clinical practice. During
the total procedure, the anesthesiologist takes the responsibility for the test
and the anesthesia status of the patient. The anesthesiologist assistant will
not take part in the test procedure, and is therefore fully dedicated to the
patient. The presence of both the anesthesiologist and anesthesiologist
assistant during the tests provides an extra level of security
High tech Campus 34
5656 AE Eindhoven
NL
High tech Campus 34
5656 AE Eindhoven
NL
Listed location countries
Age
Inclusion criteria
have an indication for elective vascular surgery, under general anesthesia
ASA 1-3
accept informed consent
availablity of study team
Exclusion criteria
known to be pregnant
ASA 4, or urgent surgery
under the age of 18
known to have cancer or an other life-threatening co-morbidity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36766.008.11 |