The purpose of this study is to gain experience and expertise with simultaneous recordings and with analyses of the accompanying datasets.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Onderzoek naar de cognitieve-, aandachts- en geheugenprocessen bij gezonde vrijwilligers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Brain function: extent of fMRI activation (number and spatial distribution of
significantly activated voxels).
Psychophysiological function: Event-related potentials and EEG frequency data.
Recruitment
Secondary outcome
nvt
Background summary
Both functional Magnetic Resonance Imaging (fMRI) and Electro-Encephalography
(EEG) are well-established research tools of investigating how the brain
responds to external events. In fMRI this is achieved by investigating the
blood-oxygenation-level-dependent (BOLD) response. Using this it is possible to
localize which regions are active during a certain event. However, since this
signal is measured indirectly trough the BOLD response the temporal resolution
is low. In EEG the neuronal electrical activity is measured from the scalp.
This means it provides a direct measure of brain activity. However, the source
in EEG is difficult to pin down. Integrating these research tools means the
high spatial resolution of fMRI can be combined with the high temporal
resolution of EEG. Furthermore, when simultaneously recording is applied
several testing artifacts can be ruled out, namely order effects, differences
in sensory stimulation, subjective experience and behavior.
Study objective
The purpose of this study is to gain experience and expertise with simultaneous
recordings and with analyses of the accompanying datasets.
Study design
The imaging study will take place in the radiology department of the Erasmus MC
in one of the MRI scanners. The total scan time shall not exceed 90 minutes.
There is no contrast agent administered during the scan. During the
investigation, the volunteer is in contact with the researcher. At any time,
the volunteer can stop the scan. In structural sequences (eg DTI) the
volunteer will lie still in the scanner. During functional MRI will the subject
will be offered stimuli (visual, tactile and / or auditory) and the volunteer
will be asked to perform commands (moving body parts, watch a video screen,
hear a sound, cognitive tasks , pressing response buttons). These commands are
hardly taxing on the subject and already tested and optimized.
Study burden and risks
There are no risks associated with the MRI scan if the volunteer is screened
for MRI contra-indications. The scan will last for a maximum of 90 minutes.
's Gravendijkwal 230
3015 CE
NL
's Gravendijkwal 230
3015 CE
NL
Listed location countries
Age
Inclusion criteria
Informed consent
> 18 years old
Healthy
Able to speak and understand Dutch
Able to perform given tasks
Exclusion criteria
MRI contraindications
Epilepsy (due to EEG)
Use of drugs and/or /medication that will influence testresults
Pregnancy
Clautrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36868.078.11 |