Dopamine on top of standard treatment for patients with exacerbation of Heart Failure, at home situation

Acute HF is defined as gradual or rapid changes in signs and symptoms of HF
that require urgent therapy. 3 In acute decompensated heart failure, the
immediate goal is to re-establish adequate perfusion and oxygen delivery to end
organs. 4 Initial therapy of acute decomposated HF usually includes combination
of an vasodilator such as nitroglycerine, diuretics, oxygeen supply and
morfine. Inotropics, like dobutamine en dopamine, milrinone are usually used
when the asbove mentiond treatment is not sufficient. 2

The current study is a prospective, randomized single centre, open label
trial. In this trial patients will be included that not need to be hospitalized
for the decompensated heart failure but can be recompensted with additional
diuretics intra venous at home setting. The home treatent will be accompanied
by the specialized nurses of the Chance@home team of the Isala klinieken. The
patients that are randomized to Dopamine will receive 24 hours Dopamine on top
of the standard treatement.

The primary objective of this randomized, open label single centre trial is to
compare dopamine versus no dopamine on top of standard treatment in patients
with exacerbation of severe heart failure (NYHA class III-IV) in home
situation. This study will investigate whether 24 hour dopamine infusion
reduces the need of hospital admission for patients with exacerbation heart
failure.

Single centre, randomized, open study

Patients who are randomized to Dopamine will get a Dopamine infusion during 24
hours +- 6 hr.

Minimal burden due to the 24 hours Dopamine infusion and blood draw of 2 extra
blood tubes (during regular blood taking)