The objective of this study is to gain insight in HIV infected children in the AMC in:.- the prevalence and clinical signs of livertoxicity - an association between the different compounds of combination anti-retroviral therapy (cART) and…
ID
Source
Brief title
Condition
- Hepatic and hepatobiliary disorders
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
livertoxicity
Secondary outcome
n.a.
Background summary
Livertoxicity in HIV infected patients has been associated with the
combinatioen treatment these HIV infected aptients use, the HIV infection
itself and various other viruses such as hepatitis C.
In teh AMC we have recently discovered that in four out of the 56 HIV infected
children, various degrees of livertoxicity were noted. Because of the high
incidence of this serious disorder in our population and the lack pof symptoms
of the HIV inffected children with livertoxicity, we think it is necessary to
screen all HIV infected children. For an appropriate comparison, we will
compare livertoxicity in HIV infected children with children without an HIV
infection.
Study objective
The objective of this study is to gain insight in HIV infected children in the
AMC in:.
- the prevalence and clinical signs of livertoxicity
- an association between the different compounds of combination anti-retroviral
therapy (cART) and livertoxicity
- correlations between biochemical markers and non-invasive ultrasonography for
to detection livertoxicity in HIV infected children
Study design
After written informed consent, 10 cc of blood will be taken from HIV infected
children and tested biochemical amrkers of livertoxicity. Furthermore two
different ultrasound of the liver will be performed, one standard ultrasound
and one elastography of the liver. The study is finished after these tests.
Study burden and risks
see above
Meibergdreef 9
1105 AZ Amsterdam
NL
Meibergdreef 9
1105 AZ Amsterdam
NL
Listed location countries
Age
Inclusion criteria
Cases are 56 HIV infected children < 18 years of age that are currently being treated in Emma Children's Hospital AMC Amsterdam.
Controles are sex, ethnicity and age matched children without a HIV infection with functional abdominal pains and in whom (because of standard patient care) blooddrawings and abdominal ultrasound inevstigations are planned or healthy siblings of HIV infected children.
For both groups written informed consent is needed
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35404.018.11 |