To develop a reproducible and valid method for measuring muscle power and to assess main underlying determinants, i.e. activation dynamics, fibre typing and controller function.
ID
Source
Brief title
Condition
- Other condition
- Muscle disorders
Synonym
Health condition
spierveroudering
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference in maximal muscle power between young and old during both
release experiments and continuous movements.
Secondary outcome
Power will be related to activation dynamics, short-range stiffness, controller
function, functional fibre typing (by
measuring short-range stiffness and activation dynamics) and handgrip strength.
Also test-retest reproducibility will be assessed.
Background summary
Sarcopenia is an age-related decrease in muscle mass associated with functional
impairment, increased likelihood of falls, and loss of autonomy. Previous
studies showed that not only muscle mass, but alterations in the overall
neuromuscular control system determine health in the elderly. Main determinants
may be changes in muscle architecture and muscle fibre type, i.e. number, size
and composition, and deterioration of controller function and activation
dynamics. The relation between main underlying determinants of muscle ageing
and functional decline is yet unclear. Muscle power, i.e. the force that can be
generated within a certain time, is strongly associated with functional decline
and seems to be more vulnerable to the process of human ageing than muscle
strength. The dependence of muscle power on both contractile force and velocity
may be responsible for that. However, measuring muscle power has several
methodological dfficulties. Most of the currently existing methods do not
fulfil minimal requirements for a proper power measurement and are not able to
analyse the contribution of main underlying determinants to the loss of muscle
power.
Study objective
To develop a reproducible and valid method for measuring muscle power and to
assess main underlying determinants, i.e. activation dynamics, fibre typing and
controller function.
Study design
A haptic wrist manipulator will be used for the assessment of muscle power,
activation dynamics and short-range stiffness. Power assessment will be
performed during continuous movement and release experiments, i.e. force
generation guided by visual feedback and sudden release of the manipulator
handle. Furthermore, test-retest reproducibility, anthropometrics, short
physical performance battery, mini-mental state examination and handgrip
strength will be measured.
Intervention
Use of haptic wrist manipulator to assess muscle power, activation dynamics and
short-range stiffness.
Study burden and risks
Measurements are non-invasive, have minimal risks and require minimal physical
and mental effort of the subject. Results of the study are important for
understanding the relation between ageing muscle and functional decline to
finally be able to distinguish different clinical phenotypes and to develop
targeted therapies.
Postbus 9600
2300 RC Leiden
NL
Postbus 9600
2300 RC Leiden
NL
Listed location countries
Age
Inclusion criteria
healthy young adults, age ranges 20 - 30 yrs
eldery, age ranges 70 - 80 yrs, free living, ADL independent
Exclusion criteria
MMSE (mini-mental state examination) < 23
SPPB (short-physical performance battery) < 10
sports on highly competitive level
sedentary lifestyle
co-morbidity: neurological disorders, metabolic disorders, arthritis, cancer
medication: immunosuppressive drugs, insulin
fracture last half year
hip/knee replacement last two years
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL35763.058.11 |