Primary Objective: The primary goal of this research project is to provide input data for a biomechanical simulation model of the knee and to determine the variation among subjects. With the simulation model ACL reconstruction can be optimised.…
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- Other condition
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Health condition
Healthy subjects
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
From MRI measurement:
a. The length and the elongation of all 4 ligaments during several flexion
position and maximal tibial rotation while the knee is in 90o flexion
b. The contact points of both femoral condyles and tibia plateau
c. The attachment position of every ligament (origin and insertion)
d. The geometric data of the knee bone, such as the widht of femoral condyle,
tibia plateau, varus valgus knee angle, the orientation of contact point
between articular cartilage and meniscus.
From Vicon measurement:
a. Kinematics of relevant body segments
b. EMG analog data of muscle activity, onset and off set of muscle activity and
muscle activity pattern.
Secondary outcome
From MRI measurement:
a. The relationship of the length of ACL, PCL, MCL and LCL in different angle
position during flexion and maximal tibia rotation at 90o knee flexion
Background summary
ACL-reconstructions are often performed in the Netherlands. The surgical
techniques used depend on the instrumentation and those are developed for an
average patient. However, patients differ in knee geometry and knee
biomechanics. As a result in several cases complications occur after surgery,
the anatomical reconstruction is not always optimal and rotational stability is
not repaired completely. Due to those reasons, a patient-specific
musculoskeletal model will be built in order to study and optimize
patient-tailored ACL reconstruction.
The musculoskeletal model will be built using Anybody software from Aalborg
University, Denmark. The model will consist of bones, muscles and ligaments.
MRI scanning will be used to get the geometrical data of the knee. Scanning
will be done in several different knee flexions. Kinematics of the model will
be derived from the registration (via optical markers on bony landmarks) of
active movements that will be recorded under 8 optical cameras of the Vicon
system in the UMCG Gait Laboratory. Normal walking, forward hopping and side
jumping will be choosen as the activities, as those activities are the standard
procedure in the rehabilitation program of ACL reconstructed-patients. During
this experiment also muscle activity will be registered with non-invasive EMG
surface electrodes. These data will be used to validate the numerical model.
Geometrical data from MRI scanning is composed of:
a. the length of 4 ligaments (the most significant ligaments in the knee) -
Anterior Cruciate Ligament (ACL), Posterior Cruciate Ligament (PCL), Medial
Collateral Ligament (MCL) and Lateral Collateral Ligament (LCL) in several
position of knee flexion (0o, 30o, 60o, 90o, full flexion, maximum internal and
external tibia rotation in 90o).
b. Attachment position of all four ligaments
c. Contact points between the two femoral condyles and the tibia plateaus at
several flexion positions as mentioned above. (knee flexion and maximum tibial
rotation)
d. Bone geometry (including articular surfaces, width and length of the femoral
condyles and tibial plateau)
e. The twisting behaviour of four ligaments as a function of the flexion angle
and maximal tibial rotation
Ìn order to fix the leg during scanning, a polymer (MRI compatible) leg fixator
will be used
Study objective
Primary Objective: The primary goal of this research project is to provide
input data for a biomechanical simulation model of the knee and to determine
the variation among subjects. With the simulation model ACL reconstruction can
be optimised.
Primary questions:
1. From the MRI measurements: What is the geometry of all relevant knee
structures (bones, ligaments and articular cartilages)? And how are the
variations among different subjects?
2. From the Vicon measurements: What are the kinematics of body segments during
normal walking, forward hopping and sidewards jumping? And how are the
variations among different subjects?
3. From the Vicon measurements: Muscle activity, duration of muscle activity,
onset and offset of relevant muscles (3 Hamstring, Quadriceps Medialis and
Lateralis, 2 Gastrocnemius, Tibialis Anterior), muscle recruitment pattern
during movement? And how are the variations among different subjects?
Secondary Objective(s): As secondary goals, we will investigate:
1) From the MRI measurements: how is the relationship of all 4 ligaments
properties (elongating, twisting) and femoral-tibial contact points during
several knee flexion positions and maximum tibial rotation? And how are the
variations among different subjects?
Study design
Experimental pilot study
Study burden and risks
a) For MRI scanning, the subject will be lying inside the MRI tube, with the
right knee flexed at 0o, 30o, 60o, 90o, full flexion, maximum internal and
external tibia rotation under 90o knee flexion using the leg fixator. For every
angle of flexion/tibia rotation, the subject will be scanned for 7 minutes, so
in total with 3 minutes break after every scanning time will be 7 minutes x 7
positions = 49 minutes + (3 minutes x 6 times break = 18 minutes),
approximately 1 hours. There is no risk associated with this experiment.
b) For the Vicon Measurements, the subject will get markers and EMG surface
electrodes attached to certain positions of the leg, then normal walking will
be performed at the first measurement, continued by forward hopping over 1 m.
The third measurment will be side jumping for 10 seconds, with a distance
between each step of 60 cm, and a jumping height of 20 cm. During all those
tasks, a force plate is applied to calculate the ground reaction force of the
subject. Every task will be performed 3 times. Every subject will need about 15
minutes for these experiments; attaching the markers and EMG surface electrodes
will take about 30 minutes, so in total the measurements will take
approximately 45 min.
The risk associated with this experiment is twisting the ankle
Antonius Deusinglaan 1, FB41
9713 AV, Groningen
NL
Antonius Deusinglaan 1, FB41
9713 AV, Groningen
NL
Listed location countries
Age
Inclusion criteria
The healthy subjects should be able to do the walking hopping task without any help or trouble. Age range should be between 18- 55 years.
Exclusion criteria
Subject is not eligible if she/he meets one or more of the following criteria: ;(a) Claustrophobic subject will be erased from the list (for MRI scanning)
(b) Current pain in the knee or other lower limb parts that can cause abnormal walking, hopping and side jumping.
(c) Past lower limb trauma that has caused current imbalance in walking and hopping
(d) Current neurological and metabolic disorders that have effect on lower limb function (diagnosed by sports physician)
(e) Current inflammatory arthritis of foot, ankle, knee, hip and back (diagnosed by sports physician)
(f) Lack of normal lower extremity function that interferes with normal walking, hopping and side jumping (diagnosed by sports physician)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL36663.042.11 |